[HTML][HTML] Neuropathic pain: from mechanisms to treatment
Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a
common chronic pain condition with major impact on quality of life. Examples include …
common chronic pain condition with major impact on quality of life. Examples include …
Modeling Alzheimer's disease with iPSC-derived brain cells
Alzheimer's disease is a devastating neurodegenerative disorder with no cure. Countless
promising therapeutics have shown efficacy in rodent Alzheimer's disease models yet failed …
promising therapeutics have shown efficacy in rodent Alzheimer's disease models yet failed …
Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine
Microglial function declines during aging. The interaction of microglia with the gut microbiota
has been well characterized during development and adulthood but not in aging. Here, we …
has been well characterized during development and adulthood but not in aging. Here, we …
Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice
Microglia are brain-resident immune cells with a repertoire of functions in the brain.
However, the extent of their interactions with the vasculature and potential regulation of …
However, the extent of their interactions with the vasculature and potential regulation of …
Microglia emerge as central players in brain disease
MW Salter, B Stevens - Nature medicine, 2017 - nature.com
There has been an explosion of new findings recently giving us insights into the involvement
of microglia in central nervous system (CNS) disorders. A host of new molecular tools and …
of microglia in central nervous system (CNS) disorders. A host of new molecular tools and …
APOE4 causes widespread molecular and cellular alterations associated with Alzheimer's disease phenotypes in human iPSC-derived brain cell types
Summary The apolipoprotein E4 (APOE4) variant is the single greatest genetic risk factor for
sporadic Alzheimer's disease (sAD). However, the cell-type-specific functions of APOE4 in …
sporadic Alzheimer's disease (sAD). However, the cell-type-specific functions of APOE4 in …
High-dimensional single-cell mapping of central nervous system immune cells reveals distinct myeloid subsets in health, aging, and disease
D Mrdjen, A Pavlovic, FJ Hartmann, B Schreiner… - Immunity, 2018 - cell.com
Individual reports suggest that the central nervous system (CNS) contains multiple immune
cell types with diverse roles in tissue homeostasis, immune defense, and neurological …
cell types with diverse roles in tissue homeostasis, immune defense, and neurological …
Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential
Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …
Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development
Neuronal synapse formation and remodeling are essential to central nervous system (CNS)
development and are dysfunctional in neurodevelopmental diseases. Innate immune …
development and are dysfunctional in neurodevelopmental diseases. Innate immune …
Microglia drive transient insult-induced brain injury by chemotactic recruitment of CD8+ T lymphocytes
Z Shi, P Yu, WJ Lin, S Chen, X Hu, S Chen, J Cheng… - Neuron, 2023 - cell.com
The crosstalk between the nervous and immune systems has gained increasing attention for
its emerging role in neurological diseases. Radiation-induced brain injury (RIBI) remains the …
its emerging role in neurological diseases. Radiation-induced brain injury (RIBI) remains the …