Chromosomal instability: a key driver in glioma pathogenesis and progression
Chromosomal instability (CIN) is a pivotal factor in gliomas, contributing to their complexity,
progression, and therapeutic challenges. CIN, characterized by frequent genomic alterations …
progression, and therapeutic challenges. CIN, characterized by frequent genomic alterations …
Molecular landscapes of glioblastoma cell lines revealed a group of patients that do not benefit from WWOX tumor suppressor expression
Ż Kałuzińska-Kołat, D Kołat, K Kośla… - Frontiers in …, 2023 - frontiersin.org
Introduction Glioblastoma (GBM) is notorious for its clinical and molecular heterogeneity,
contributing to therapeutic failure and a grim prognosis. WWOX is one of the tumor …
contributing to therapeutic failure and a grim prognosis. WWOX is one of the tumor …
Pervasive structural heterogeneity rewires glioblastoma chromosomes to sustain patient-specific transcriptional programs
T Xie, A Danieli-Mackay, M Buccarelli… - Nature …, 2024 - nature.com
Glioblastoma multiforme (GBM) encompasses brain malignancies marked by phenotypic
and transcriptional heterogeneity thought to render these tumors aggressive, resistant to …
and transcriptional heterogeneity thought to render these tumors aggressive, resistant to …
CDKN2A promoter methylation enhances self-renewal of glioblastoma stem cells and confers resistance to carmustine
J Wang, Y Xi, Q Zhao, J Guo, Z Zhang, M Zhang… - Molecular Biology …, 2024 - Springer
Background Glioblastoma, a highly aggressive form of brain cancer, poses significant
challenges due to its resistance to therapy and high recurrence rates. This study aimed to …
challenges due to its resistance to therapy and high recurrence rates. This study aimed to …
Application of novel PACS-based informatics platform to identify imaging based predictors of CDKN2A allelic status in glioblastomas
Gliomas with CDKN2A mutations are known to have worse prognosis but imaging features
of these gliomas are unknown. Our goal is to identify CDKN2A specific qualitative imaging …
of these gliomas are unknown. Our goal is to identify CDKN2A specific qualitative imaging …
Clinically Available and Reproducible Prediction Models for IDH and CDKN2A/B Gene Status in Adult-type Diffuse Gliomas
ML Zhu, F Han, JH Gao, J Yang, LL Yin, ZG Du… - Academic …, 2024 - Elsevier
Purpose Isocitrate dehydrogenase (IDH) and cyclin-dependent kinase inhibitor (CDKN)
2A/B status holds important prognostic value in diffuse gliomas. We aimed to construct …
2A/B status holds important prognostic value in diffuse gliomas. We aimed to construct …
Prognostic Impact of CDKN2A Mutations Associated With Smoking and Drinking History in Japanese Digestive Cancers
K Fujita, M Hayashi, N Nakagawa… - Anticancer …, 2024 - ar.iiarjournals.org
Background/Aim: Organs of the digestive system are frequent sites of cancer development,
and digestive tract cancers are the leading causes of death worldwide, including in Japan …
and digestive tract cancers are the leading causes of death worldwide, including in Japan …
Durable benefit and slowdown in tumor growth dynamics with erdafitinib in a FGFR3-TACC3 fusion-positive IDH-wild type glioblastoma
S Cabezas-Camarero, R Pérez-Alfayate… - Neuro-Oncology …, 2024 - academic.oup.com
FGFR3-TACC3 fusion-positive IDH-wild-type (IDH-WT) glioblastoma (GB) is a rare GB
subtype occurring in approximately 3% of cases. It is clinical behavior and molecular profile …
subtype occurring in approximately 3% of cases. It is clinical behavior and molecular profile …
Extreme structural heterogeneity rewires glioblastoma chromosomes to sustain patient-specific transcriptional programs
T Xie, A Danieli-Mackay, M Buccarelli, M Barbieri… - bioRxiv, 2023 - biorxiv.org
Glioblastoma multiforme (GBM) encompasses brain malignancies marked by phenotypic
and transcriptional heterogeneity thought to render these tumors aggressive, resistant to …
and transcriptional heterogeneity thought to render these tumors aggressive, resistant to …
Optimizing Recurrent Glioblastoma Salvage Treatment: A Multicenter Study Integrating Genetic Biomarkers From the Korean Radiation Oncology Group (21-02)
D Kim, JH Lee, N Kim, DH Lim, JH Song, CO Suh… - …, 2024 - journals.lww.com
METHODS: We assessed 468 adult patients with rGBM who underwent standard
temozolomide-based chemoradiation. The impact of predictors on PPS was evaluated in …
temozolomide-based chemoradiation. The impact of predictors on PPS was evaluated in …