The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities …

Major depressive disorder (MDD), also referred to as depression, is one of the most common
psychiatric disorders with a high economic burden. The etiology of depression is still not …

Recent studies have provided promising evidence that neuroimaging data can predict
treatment outcomes for patients with major depressive disorder (MDD). As most of these …

Major depressive disorder is among the most prevalent psychiatric disorders, exacting a
substantial personal, social, and economic toll. Antidepressant treatment typically involves …

Altered synaptic plasticity is often associated with major depressive disorder (MDD).
Disease-associated changes in synaptic functions are tightly correlated with altered …

No tools are currently available to predict whether a patient suffering from major depressive
disorder (MDD) will respond to a certain treatment. Machine learning analysis of magnetic …

The prediction of antidepressant response is critical for psychiatrists to select the initial
antidepressant drug for patients with major depressive disorders (MDD). The implicated …

Neural markers of pathophysiological processes underlying the dimension of subsyndromal-
syndromal-level depression severity can provide objective, biologically informed targets for …

Severe mental illnesses (SMI) collectively affect approximately 20% of the global population,
as estimated by the World Health Organization (WHO). Despite having diverse etiologies …

Background Early‐onset (EO) major depressive disorder (MDD) patients experience more
depressive episodes and an increased risk of relapse. Thus, on a neurobiological level …