Diffuse intrinsic pontine gliomas (DIPGs) are amongst the most challenging tumors to treat.
Surgery is not an option, the effects of radiation therapy are temporary, and no …

High-grade pediatric central nervous system glial tumors are comprised primarily of
anaplastic astrocytomas (AA, WHO grade III) and glioblastomas (GBM, WHO grade IV). High …

Purpose Diffuse intrinsic pontine glioma (DIPG) is one of the most devastating of pediatric
malignancies and one for which no effective therapy exists. A major contributor to the failure …

Patients with diffuse intrinsic pontine gliomas (DIPG) have a poor prognosis. Although DIPG
constitute only 10–15% of all pediatric brain tumors, they are the main cause of death in this …

Gliomas in children differ from their adult counterparts by their distribution of histological
grade, site of presentation and rate of malignant transformation. Although rare in the …

Malignant brain tumors are the leading cause of cancer death among children and the
second most common type of pediatric cancer. Despite several decades of epidemiologic …

Abstract Learning Objectives After completing this course, the reader will be able to:
Describe the known genetic alterations associated with pediatric supratentorial high-grade …

Purpose Recent studies have demonstrated a high frequency of IDH mutations in adult
“secondary” malignant gliomas arising from preexisting lower grade lesions, often in young …

Diffuse intrinsic pontine glioma (DIPG) is a devastating pediatric brain cancer with no
effective therapy. Histological similarity of DIPG to supratentorial high-grade astrocytomas of …

Brainstem gliomas (BSG) are a rare group of central nervous system tumors that arise mostly
in children and usually portend a particularly poor prognosis. We report the development of …