Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options

D Liu, SY Huang, JH Sun, HC Zhang, QL Cai… - Military Medical …, 2022 - Springer
Sepsis is a common complication of combat injuries and trauma, and is defined as a life-
threatening organ dysfunction caused by a dysregulated host response to infection. It is also …

Keeping T cell memories in mind

MR Mix, JT Harty - Trends in immunology, 2022 - cell.com
The mammalian central nervous system (CNS) contains a vibrant community of resident
adaptive immune cells at homeostasis. Among these are memory CD8+ and CD4+ T cells …

[HTML][HTML] Lymphohematopoietic graft-versus-host responses promote mixed chimerism in patients receiving intestinal transplantation

J Fu, J Zuber, B Shonts, A Obradovic… - The Journal of …, 2021 - Am Soc Clin Investig
In humans receiving intestinal transplantation (ITx), long-term multilineage blood chimerism
often develops. Donor T cell macrochimerism (≥ 4%) frequently occurs without graft-versus …

Down-regulation of lncRNA SNHG5 relieves sepsis-induced acute kidney injury by regulating the miR-374a-3p/TLR4/NF-κB pathway

M Wang, J Wei, F Shang, K Zang… - The journal of …, 2021 - academic.oup.com
Sepsis is an acute systemic infectious disease engendered by infectious factors, which can
cause the dysfunction of multiple organs, including acute kidney injury (AKI). Recently, more …

Sepsis impedes EAE disease development and diminishes autoantigen-specific naive CD4 T cells

IJ Jensen, SN Jensen, FV Sjaastad, KN Gibson-Corley… - Elife, 2020 - elifesciences.org
Evaluation of sepsis-induced immunoparalysis has highlighted how decreased lymphocyte
number/function contribute to worsened infection/cancer. Yet, an interesting contrast exists …

Advances in the study of immunosuppressive mechanisms in sepsis

X Fu, Z Liu, Y Wang - Journal of Inflammation Research, 2023 - Taylor & Francis
Sepsis is a life-threatening disease caused by a systemic infection that triggers a
dysregulated immune response. Sepsis is an important cause of death in intensive care …

T‐cell memory in tissues

KPJM van Gisbergen, KD Zens… - European journal of …, 2021 - Wiley Online Library
Immunological memory equips our immune system to respond faster and more effectively
against reinfections. This acquired immunity was originally attributed to long‐lived, memory …

TLR2-induced CD8+ T-cell deactivation shapes dendritic cell differentiation in the bone marrow during sepsis

AC Antoni, E Pylaeva, B Budeus, J Jablonska… - Frontiers in …, 2022 - frontiersin.org
Sepsis is associated with profound immune dysregulation that increases the risk for life-
threatening secondary infections: Dendritic cells (DCs) undergo functional reprogramming …

An early myelosuppression in the acute mouse sepsis is partly outcome-dependent

T Skirecki, S Drechsler, A Jeznach, G Hoser… - Frontiers in …, 2021 - frontiersin.org
Adult hematopoietic stem and progenitor cells (HSPCs) respond to bacterial infections by
expansion to myeloid cells. Sepsis impairs this process by suppressing differentiation of …

[PDF][PDF] 脓毒症免疫抑制相关效应T 细胞亚群稳态失衡的研究进展

张文钊, 王志斌 - 中华危重病急救医学, 2022 - cccm-em120.com
脓毒症免疫抑制相关效应T 细胞亚群稳态失衡的研究进展 Page 1 · 95 · 中华危重病急救医学2022
年1 月第34 卷第1 期Chin Crit Care Med,January 2022,Vol.34,No.1 ·综述· 脓毒症免疫抑制相关 …