Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …

Traditional Chinese medicine plays a significant role in the treatment of various diseases
and has attracted increasing attention for clinical applications. Vascular diseases affecting …

Vascular smooth muscle cells (VSMCs) are integral to the pathophysiology of cardiovascular
diseases (CVDs). Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase, plays a …

Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects
the survival of aerobic species and plays a prominent role in cardiovascular diseases. From …

Pathogenic DNA methylation changes may be involved in pulmonary arterial hypertension
(PAH) onset and its progression, but there is no data on potential associations with patient …

Pulmonary arterial hypertension (PAH) is a multifactorial disease associated with the
remodeling of pulmonary blood vessels. If left unaddressed, PAH can lead to right heart …

Pulmonary vascular remodeling is the critical structural alteration and pathological feature in
pulmonary hypertension (PH) and involves changes in the intima, media and adventitia …

A major barrier to the impact of genomic diagnosis in patients with congenital malformations
is the lack of understanding regarding how sequence variants contribute to disease …

Pulmonary arterial hypertension (PAH) is a severe progressive disease that may cause early
right ventricular failure and eventual cardiac failure. The pathogenesis of PAH involves …

Pulmonary arterial hypertension (PAH) is a rare disease characterized by high blood
pressure in the pulmonary circulation driven by pathological remodeling of distal pulmonary …