The human genetic epidemiology of COVID-19
Human genetics can inform the biology and epidemiology of coronavirus disease 2019
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …
Challenges and opportunities for developing more generalizable polygenic risk scores
Polygenic risk scores (PRS) estimate an individual's genetic likelihood of complex traits and
diseases by aggregating information across multiple genetic variants identified from genome …
diseases by aggregating information across multiple genetic variants identified from genome …
Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality
T Nakanishi, S Pigazzini, F Degenhardt… - The Journal of …, 2021 - Am Soc Clin Investig
Background There is considerable variability in COVID-19 outcomes among younger adults,
and some of this variation may be due to genetic predisposition. Methods We combined …
and some of this variation may be due to genetic predisposition. Methods We combined …
GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia
GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights
a potential causal role in dementia | eLife Skip to Content eLife logo eLife home page Menu …
a potential causal role in dementia | eLife Skip to Content eLife logo eLife home page Menu …
ADuLT: An efficient and robust time-to-event GWAS
Proportional hazards models have been proposed to analyse time-to-event phenotypes in
genome-wide association studies (GWAS). However, little is known about the ability of …
genome-wide association studies (GWAS). However, little is known about the ability of …
Germline mechanisms of immunotherapy toxicities in the era of genome‐wide association studies
A Gusev - Immunological Reviews, 2023 - Wiley Online Library
Cancer immunotherapy has revolutionized the treatment of advanced cancers and is quickly
becoming an option for early‐stage disease. By reactivating the host immune system …
becoming an option for early‐stage disease. By reactivating the host immune system …
Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research
Psychiatric disorders are highly comorbid, heritable, and genetically correlated [,,–]. The
primary objective of cross-disorder psychiatric genetics research is to identify and …
primary objective of cross-disorder psychiatric genetics research is to identify and …
An axis of genetic heterogeneity in autism is indexed by age at diagnosis and is associated with varying developmental and mental health profiles
X Zhang, J Grove, Y Gu, CK Buus, LK Nielsen… - Medrxiv, 2024 - pmc.ncbi.nlm.nih.gov
There is growing recognition that earliest signs of autism need not clearly manifest in the first
three years of life. To what extent is this variation in developmental trajectories associated …
three years of life. To what extent is this variation in developmental trajectories associated …
Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records
The association between coronary artery disease (CAD) and posttraumatic stress disorder
(PTSD) contributes to the high morbidity and mortality observed for these conditions. To …
(PTSD) contributes to the high morbidity and mortality observed for these conditions. To …
Limited overlap between genetic effects on disease susceptibility and disease survival
Z Yang, FD Pajuste, K Zguro, Y Cheng, DE Kurant… - medRxiv, 2023 - medrxiv.org
Understanding disease progression is of a high biological and clinical interest. Unlike
disease susceptibility whose genetic basis has been abundantly studied, less is known …
disease susceptibility whose genetic basis has been abundantly studied, less is known …