Intestinal fibrosis, which is usually the consequence of chronic inflammation, is a common
complication of inflammatory bowel disease (IBD), including Crohn's disease and ulcerative …

In the last 10 years, we have learned much about the pathogenesis, diagnosis, and
management of intestinal fibrosis in patients with inflammatory bowel diseases. Just a …

The intestinal extracellular matrix (ECM) represents a complex network of proteins that not
only forms a support structure for resident cells but also interacts closely with them by …

Background & Aims Intestinal fibrosis is a long-term complication in inflammatory bowel
diseases (IBD) that frequently results in functional damage, bowel obstruction, and surgery …

As a main digestive organ and an important immune organ, the intestine plays a vital role in
resisting the invasion of potential pathogens into the body. Intestinal immune dysfunction …

Importance of chronic fibroproliferative diseases (FDs) including pulmonary fibrosis, chronic
kidney diseases, inflammatory bowel disease, and cardiovascular or liver fibrosis is rapidly …

The intestine is composed of many distinct cell types that respond to commensal microbiota
or pathogens with immune tolerance and proinflammatory signals respectively. ROS …

Gut mucosal barriers, including chemical and physical barriers, spatially separate the gut
microbiota from the host immune system to prevent unwanted immune responses that could …

Fibrosis is a pathological process caused by abnormal wound healing response, which
often leads to excessive deposition of extracellular matrix, distortion of organ architecture …

Succinate, an intermediate of the tricarboxylic acid cycle, is accumulated in inflamed areas
and its signaling through succinate receptor (SUCNR1) regulates immune function. We …