Ocular lens development entails epithelial to fiber cell differentiation, defects in which cause
congenital cataracts. We report the first single-cell multiomic atlas of lens development …

Retinal ischemia exists in various ischemic retinopathies including glaucoma, contributing to
the death of retinal neurons. Calcium binding protein S100A4 is important in tumors, and our …

One of the most prevalent disorders that cause blindness worldwide is cataract, and its
essence is the visual disorder caused by the opacity of the lens. The significant degree of …

While the lens is an avascular tissue with an immune-privileged status, studies have now
revealed that there are immune responses specifically linked to the lens. The response to …

Background The benefits of physical activity for the overall well-being of elderly individuals
are well-established, the precise mechanisms through which exercise improves pathological …

The cytoarchitecture and tensile characteristics of ocular lenses play a crucial role in
maintaining their transparency and deformability, respectively, which are properties required …

Purpose: Despite strong evidence demonstrating that normal lens development requires
regulation governed by microRNAs (miRNAs), the functional role of specific miRNAs in …

Background Lens morphogenesis, architecture, and clarity are known to be critically
dependent on actin cytoskeleton organization and cell adhesive interactions. There is …

Statement This study illustrates a vital role for ankyrin-B in lens architecture, growth and
function through its involvement in membrane protein and spectrin-actin cytoskeletal …

The addition of 50% vitreous humor to the media bathing lens explants results in the
induction of both fiber cell differentiation and a significant immune/inflammatory response …