Inflammation is a major regulator of drug metabolizing enzymes and transporters: consequences for the personalization of drug treatment
F Stanke-Labesque, E Gautier-Veyret, S Chhun… - Pharmacology & …, 2020 - Elsevier
Inflammation is an evolutionary process that allows survival against acute infection or injury.
Inflammation is also a pathophysiological condition shared by numerous chronic diseases …
Inflammation is also a pathophysiological condition shared by numerous chronic diseases …
Influence of inflammation on cytochromes P450 activity in adults: a systematic review of the literature
C Lenoir, V Rollason, JA Desmeules… - Frontiers in …, 2021 - frontiersin.org
Background: Available in-vitro and animal studies indicate that inflammation impacts
cytochromes P450 (CYP) activity via multiple and complex transcriptional and post …
cytochromes P450 (CYP) activity via multiple and complex transcriptional and post …
Antifungal drugs TDM: trends and update
B Kably, M Launay, A Derobertmasure… - Therapeutic Drug …, 2022 - journals.lww.com
Purpose: The increasing burden of invasive fungal infections results in growing challenges
to antifungal (AF) therapeutic drug monitoring (TDM). This review aims to provide an …
to antifungal (AF) therapeutic drug monitoring (TDM). This review aims to provide an …
The cytokine release syndrome and/or the proinflammatory cytokines as underlying mechanisms of downregulation of drug metabolism and drug transport: a …
Abstract Background and Objective An ever-growing body of evidence supports the impact
of cytokine modulation on the patient's phenotypic drug response. The aim of this systematic …
of cytokine modulation on the patient's phenotypic drug response. The aim of this systematic …
[HTML][HTML] How to design a study to evaluate therapeutic drug monitoring in infectious diseases?
AG Märtson, MGG Sturkenboom, J Stojanova… - Clinical Microbiology …, 2020 - Elsevier
Background Therapeutic drug monitoring (TDM) is a tool to personalize and optimize dosing
by measuring the drug concentration and subsequently adjusting the dose to reach a target …
by measuring the drug concentration and subsequently adjusting the dose to reach a target …
Posaconazole therapeutic drug monitoring in clinical practice and longitudinal analysis of the effect of routine laboratory measurements on posaconazole …
AG Märtson, A Veringa, ER van den Heuvel… - Mycoses, 2019 - Wiley Online Library
Posaconazole is indicated for prophylaxis and treatment of invasive aspergillosis.
Therapeutic drug monitoring (TDM) of posaconazole is used to optimise drug exposure. The …
Therapeutic drug monitoring (TDM) of posaconazole is used to optimise drug exposure. The …
Deciphering the relationship between the trough concentration of posaconazole and its efficacy and safety in Chinese patients with hematological disorders
MM Jia, QW Zhang, ZF Qin, RQ Lu, XK Tian… - Frontiers in …, 2020 - frontiersin.org
Posaconazole (PCZ) is effective in preventing and salvage treatment invasive fungal
infections in patients with hematologic disorders. However, PCZ displays highly variable …
infections in patients with hematologic disorders. However, PCZ displays highly variable …
Pharmacokinetics of voriconazole and its alteration by Candida albicans infection in silkworms
T Yasu, Y Matsumoto, T Sugita - The Journal of Antibiotics, 2021 - nature.com
Voriconazole (VRCZ) is a triazole antifungal agent used for the treatment and prophylaxis of
invasive fungal infections. Therapeutic drug monitoring of VRCZ is widely applied clinically …
invasive fungal infections. Therapeutic drug monitoring of VRCZ is widely applied clinically …
Modifications pharmacocinétiques liées à une infection aiguë. Exemples issus de la pandémie de SARS-CoV-2
A Chavant, E Gautier-Veyret, S Chhun, R Guilhaumou… - Therapies, 2021 - Elsevier
Résumé Afin de personnaliser la prise en charge médicamenteuse, il est important
d'identifier les facteurs de variabilité pharmacocinétique, en particulier des médicaments à …
d'identifier les facteurs de variabilité pharmacocinétique, en particulier des médicaments à …
Pharmacokinetic changes related to acute infection. Examples from the SARS-CoV-2 pandemic
A Chavant, E Gautier-Veyret, S Chhun, R Guilhaumou… - Therapie, 2020 - europepmc.org
Résumé Afin de personnaliser la prise en charge médicamenteuse, il est important
d'identifier les facteurs de variabilité pharmacocinétique, en particulier des médicaments à …
d'identifier les facteurs de variabilité pharmacocinétique, en particulier des médicaments à …