Somatostatin is a peptide with a potent and broad antisecretory action, which makes it an
invaluable drug target for the pharmacological management of pituitary adenomas and …

Primary ovarian insufficiency (POI) is determined by exhaustion of follicles in the ovaries,
which leads to infertility before the age of 40 years. It is characterized by a strong familial …

Pituitary adenomas are one of the most frequent intracranial tumors and occur with a
prevalence of approximately 1: 1000 in the developed world. Pituitary adenomas have a …

Context: AIP mutations (AIPmut) give rise to a pituitary adenoma predisposition that occurs
in familial isolated pituitary adenomas and less often in sporadic cases. The clinical and …

Context: Familial isolated pituitary adenoma (FIPA) due to aryl hydrocarbon receptor
interacting protein (AIP) gene mutations is an autosomal dominant disease with incomplete …

Context: Mutations have been identified in the aryl hydrocarbon receptor-interacting protein
(AIP) gene in familial isolated pituitary adenomas (FIPA). It is not clear, however, how this …

According to data derived from autopsy and radiological imaging series, pituitary tumours
occur very commonly in the general population; however, most of these tumours are …

Familial isolated pituitary adenoma (FIPA) is an autosomal dominant condition with variable
genetic background and incomplete penetrance. Germline mutations of the aryl hydrocarbon …

Pituitary adenomas occur in a familial setting in multiple endocrine neoplasia type 1 (MEN1)
and Carney's complex (CNC), which occur due to mutations in the genes MEN1 and …

Breast cancer cells are usually sensitive to several chemotherapeutic regimens, but they can
develop chemoresistance after prolonged exposure to cytotoxic drugs, acquiring a more …