MicroRNAs (miRNAs) participate in most aspects of cellular differentiation and homeostasis,
and consequently have roles in many pathologies, including cancer. These small non …

The ability to rationally engineer microorganisms has been a long-envisioned goal dating
back more than a half-century. With the genomics revolution and rise of systems biology in …

Biological systems use a variety of mechanisms to maintain their functions in the face of
environmental and genetic perturbations. Increasing evidence suggests that, among their …

Cellular decision making is the process whereby cells assume different, functionally
important and heritable fates without an associated genetic or environmental difference …

The genetic circuits that regulate cellular functions are subject to stochastic fluctuations, or
'noise', in the levels of their components. Noise, far from just a nuisance, has begun to be …

A central challenge of biology is to understand how individual cells process information and
respond to perturbations. Much of our knowledge is based on ensemble measurements …

The innate inflammatory response must be tightly regulated to ensure effective immune
protection. NF-κB is a key mediator of the inflammatory response, and its dysregulation has …

The variational principles called maximum entropy (MaxEnt) and maximum caliber
(MaxCal)<? format?> are reviewed. MaxEnt originated in the statistical physics of Boltzmann …

Noise permeates biology on all levels, from the most basic molecular, sub-cellular
processes to the dynamics of tissues, organs, organisms and populations. The functional …

In some recent studies, a view emerged that stochastic dynamics governing the switching of
cells from one differentiation state to another could be characterized by a peak in gene …