Restoration of euthyroidism with levothyroxine: implications of etiology of hypothyroidism and the degree of residual endogenous thyroid function

J Jonklaas - Frontiers in endocrinology, 2022 - frontiersin.org
There are many thyroid-related factors that combine with non-thyroid-related factors in order
to affect the patient response to treatment of hypothyroidism, in terms of their satisfaction with …

Model‐Informed Precision Dosing Using Machine Learning for Levothyroxine in General Practice: Development, Validation and Clinical Simulation Trial

JM Janssen Daalen, D Doesburg… - Clinical …, 2024 - Wiley Online Library
Levothyroxine is one of the most prescribed drugs in the western world. Dosing is
challenging due to high‐interindividual differences in effective dosage and the narrow …

Treating Hyperthyroidism: Model Predictive Control for the Prescription of Antithyroid Agents

TM Wolff, M Menzel, JW Dietrich, MA Müller - arXiv preprint arXiv …, 2022 - arxiv.org
In this work, we propose an approach to determine the dosages of antithyroid agents to treat
hyperthyroid patients. Instead of relying on a trial-and-error approach as it is commonly done …

CyberUnits bricks: an implementation study of a class library for simulating nonlinear biological feedback loops

JW Dietrich, N Siegmar, JR Hojjati, O Gardt… - Advances in …, 2024 - dr.ntu.edu.sg
Feedback loops and other types of information processing structures play a pivotal role in
maintaining the internal milieu of living organisms. Although methods of biomedical …

[HTML][HTML] A New Mathematical Approach for Hashimoto's Thyroiditis in Children

M Pompa, A De Gaetano, A Borri, A Farsetti, S Nanni… - Mathematics, 2024 - mdpi.com
Hashimoto's thyroiditis (HT) is a prevalent autoimmune disorder marked by chronic
inflammation of the thyroid gland, predominantly affecting children and adolescents. In a …

Fast Track Treatment of Hypothyroidism with Levothyroxine: Reaching Homeostasis within Four Weeks

SL Goede - Acta Biotheoretica, 2023 - Springer
With the current clinical method for the treatment of hypothyroidism the target for the
optimum individual values for free thyroxine concentrations [FT4] and thyrotropine …

[HTML][HTML] Современные достижения и проблемы в терапии первичного гипотиреоза

АВ Николаева, МВ Дударев… - Клиническая …, 2024 - clinmedjournal.com
Аннотация В статье представлен обзор современных подходов и проблем в ведении
пациентов с первичным гипотиреозом. В настоящее время во всем мире проводятся …

Optimizing levothyroxine dosage for hypothyroid-ism treatment: a model-based approach

D Manca - Book of abstracts, 2024 - repo.pw.edu.pl
In recent years, there has been a surge in interest in developing novel approaches for
predicting the optimal dosage of levothyroxine (LT4), a synthetic drug used in the treatment …