Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …

Autophagy is a tightly regulated catabolic process wherein cells under stress sequester
cytosolic constituents like damaged proteins and organelles in double-membrane vesicles …

BECLIN1 is a well-established regulator of autophagy, a process essential for mammalian
survival. It functions in conjunction with other proteins to form Class III Phosphoinositide 3 …

Autophagy is a conserved intracellular degradation pathway essential for protein
homeostasis, survival and development. Defects in autophagic pathways have been …

Macroautophagy/autophagy plays an important role during the development of human
cancer. BECN1 (beclin 1), a core player in autophagy regulation, is downregulated in many …

Autophagy, a main intracellular catabolic process, is induced in response to a variety of
cellular stresses to promptly degrade harmful agents and to coordinate the activity of …

Ubiquitination, the post-translational modification essential for various intracellular
processes, is implicated in multiple aspects of autophagy, the major lysosome/vacuole …

Autophagy represents a fundamental mechanism for maintaining cell survival and tissue
homeostasis in response to physiological and pathological stress. Autophagy initiation …

Beclin 1 a yeast Atg6/VPS30 orthologue has a significant role in autophagy process
(Macroautophagy) and protein sorting. The function of beclin 1 depends on the interaction …

Dysregulated proteostasis is one of the hallmarks of ageing. Damaged proteins may impair
cellular function and their accumulation may lead to tissue dysfunction and disease. This is …