Cancer stem-like cell (CSC) model has been established to investigate the underlying
mechanisms of tumor initiation and progression. The imbalance between acetylation and …

Acetylation, a key component in post-translational modification regulated by HATs and
HDACs, is relevant to many crucial cellular contexts in organisms. Based on crucial …

Over the last decade, numerous histone acyl post-translational modifications (acyl-PTMs)
have been discovered, of which the functional significance is still under intense study. Here …

The cell cycle in pluripotent stem cells is notable for the brevity of the G1 phase, permitting
rapid proliferation and reducing the duration of differentiation signal sensitivity associated …

Pancreatic Cancer (PDA) is an aggressive malignancy characterized by early spread and a
high mortality. Current studies suggest that a subpopulation of cells exist within tumors …

Epigenetic regulation is important for establishing lineage-specific gene expression during
early development. Although signaling pathways have been well-studied for regulation of …

Cell-intrinsic and extrinsic signals regulate the state and fate of stem and progenitor cells.
Recent advances in metabolomics illustrate that various metabolic pathways are also …

This in vitro study evaluated the role of photobiomodulation therapy (PBMT) on viability and
migration of human dental pulp stem cells (hDPSCs) and its association to epigenetic …

Embryonic stem cells (ESCs) are maintained in an undifferentiated state through expression
of the core transcriptional factors Nanog, Oct4, and Sox2. However, the epigenetic …

Elucidation of the epigenetic basis for cell-type specific gene regulation is key to gaining a
full understanding of how the distinct phenotypes of differentiated cells are achieved and …