New classification of endometrial cancers: the development and potential applications of genomic-based classification in research and clinical care

A Talhouk, JN McAlpine - Gynecologic oncology research and practice, 2016 - Springer
Endometrial carcinoma (EC) is the fourth most common cancer in women in the developed
world. Classification of ECs by histomorphologic criteria has limited reproducibility and …

Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification

SF Lax - Virchows Archiv, 2004 - Springer
Two types of endometrial carcinoma are distinguished with respect to biology and clinical
course. Type-I carcinoma is related to hyperestrogenism by association with endometrial …

Integrated genomic characterization of endometrial carcinoma

DA Levine… - Nature, 2013 - nature.com
We performed an integrated genomic, transcriptomic and proteomic characterization of 373
endometrial carcinomas using array-and sequencing-based technologies. Uterine serous …

Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability

A Umar, CR Boland, JP Terdiman… - Journal of the …, 2004 - academic.oup.com
Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is a
common autosomal dominant syndrome characterized by early age at onset, neoplastic …

Prognostic parameters of endometrial carcinoma

J Prat - Human pathology, 2004 - Elsevier
Endometrial carcinoma is the most common malignant tumor of the female genital tract in the
Western world. Approximately 80% of cases are well-to moderately differentiated …

Modeling endometrial cancer: past, present, and future

T Van Nyen, CP Moiola, E Colas, D Annibali… - International journal of …, 2018 - mdpi.com
Endometrial cancer is the most common type of cancer of the female reproductive tract.
Although prognosis is generally good for patients with low-grade and early-stage diseases …

Molecular pathology of endometrial hyperplasia and carcinoma

X Matias-Guiu, L Catasus, E Bussaglia, H Lagarda… - Human pathology, 2001 - Elsevier
Four different genetic abnormalities may occur in endometrioid adenocarcinomas of the
endometrium (mircosatellite instability and mutations in the PTEN, k-RAS and β-catenin …

Novel molecular profiles of endometrial cancer—new light through old windows

A Doll, M Abal, M Rigau, M Monge, M Gonzalez… - The Journal of steroid …, 2008 - Elsevier
Endometrial carcinoma (EC) is the most common gynecological malignancy in the western
world. A widely accepted dualistic model, which has been established on a morphological …

The Pan-Cancer analysis of pseudogene expression reveals biologically and clinically relevant tumour subtypes

L Han, Y Yuan, S Zheng, Y Yang, J Li… - Nature …, 2014 - nature.com
Although individual pseudogenes have been implicated in tumour biology, the biomedical
significance and clinical relevance of pseudogene expression have not been assessed in a …

Epithelial-to-mesenchymal transition in the female reproductive tract: from normal functioning to disease pathology

O Bilyk, M Coatham, M Jewer, LM Postovit - Frontiers in oncology, 2017 - frontiersin.org
Epithelial-to-mesenchymal transition (EMT) is a physiological process that is vital throughout
the human lifespan. In addition to contributing to the development of various tissues within …