Astrocyte activation in neurovascular damage and repair following ischaemic stroke

A Patabendige, A Singh, S Jenkins, J Sen… - International journal of …, 2021 - mdpi.com
Transient or permanent loss of tissue perfusion due to ischaemic stroke can lead to damage
to the neurovasculature, and disrupt brain homeostasis, causing long-term motor and …

Multifaceted role of matrix metalloproteinases in neurodegenerative diseases: Pathophysiological and therapeutic perspectives

T Behl, G Kaur, A Sehgal, S Bhardwaj, S Singh… - International Journal of …, 2021 - mdpi.com
Neurodegeneration is the pathological condition, in which the nervous system or neuron
loses its structure, function, or both, leading to progressive degeneration or the death of …

Emerging roles for dynamic aquaporin-4 subcellular relocalization in CNS water homeostasis

MM Salman, P Kitchen, A Halsey, MX Wang… - 2022 - academic.oup.com
Aquaporin channels facilitate bidirectional water flow in all cells and tissues. AQP4 is highly
expressed in astrocytes. In the CNS, it is enriched in astrocyte endfeet, at synapses, and at …

[HTML][HTML] The effects of trifluoperazine on brain edema, aquaporin-4 expression and metabolic markers during the acute phase of stroke using photothrombotic mouse …

NJ Sylvain, MM Salman, MJ Pushie, H Hou… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Stroke is the second leading cause of death and the third leading cause of disability
globally. Edema is a hallmark of stroke resulting from dysregulation of water homeostasis in …

Advances in applying computer-aided drug design for neurodegenerative diseases

MM Salman, Z Al-Obaidi, P Kitchen, A Loreto… - International journal of …, 2021 - mdpi.com
Neurodegenerative diseases (NDs) including Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis, and Huntington's disease are incurable and affect millions of …

[HTML][HTML] An overview of in vitro 3D models of the blood-brain barrier as a tool to predict the in vivo permeability of nanomedicines

A Pérez-López, AI Torres-Suárez… - Advanced Drug Delivery …, 2023 - Elsevier
The blood–brain barrier (BBB) prevents efficient drug delivery to the central nervous system.
As a result, brain diseases remain one of the greatest unmet medical needs. Understanding …

Pathophysiological responses and roles of astrocytes in traumatic brain injury

S Michinaga, Y Koyama - International journal of molecular sciences, 2021 - mdpi.com
Traumatic brain injury (TBI) is immediate damage caused by a blow to the head resulting
from traffic accidents, falls, and sporting activity, which causes death or serious disabilities in …

High-throughput screening platforms in the discovery of novel drugs for neurodegenerative diseases

H Aldewachi, RN Al-Zidan, MT Conner, MM Salman - Bioengineering, 2021 - mdpi.com
Neurodegenerative diseases (NDDs) are incurable and debilitating conditions that result in
progressive degeneration and/or death of nerve cells in the central nervous system (CNS) …

Microfluidic tissue engineering and bio‐actuation

M Filippi, T Buchner, O Yasa, S Weirich… - Advanced …, 2022 - Wiley Online Library
Bio‐hybrid technologies aim to replicate the unique capabilities of biological systems that
could surpass advanced artificial technologies. Soft bio‐hybrid robots consist of synthetic …

Military traumatic brain injury: a challenge straddling neurology and psychiatry

LZ Kong, RL Zhang, SH Hu, JB Lai - Military medical research, 2022 - Springer
Military psychiatry, a new subcategory of psychiatry, has become an invaluable, intangible
effect of the war. In this review, we begin by examining related military research …