Telomere-mediated lung disease
JK Alder, M Armanios - Physiological reviews, 2022 - journals.physiology.org
Parenchymal lung disease is the fourth leading cause of death in the United States; among
the top causes, it continues on the rise. Telomeres and telomerase have historically been …
the top causes, it continues on the rise. Telomeres and telomerase have historically been …
Diabetes, metabolic disease, and telomere length
Telomeres are regions of repetitive nucleotide sequences at the ends of chromosomes.
Telomere length is a marker of DNA damage, which is often considered a biomarker for …
Telomere length is a marker of DNA damage, which is often considered a biomarker for …
[HTML][HTML] Loss of epigenetic information as a cause of mammalian aging
All living things experience an increase in entropy, manifested as a loss of genetic and
epigenetic information. In yeast, epigenetic information is lost over time due to the …
epigenetic information. In yeast, epigenetic information is lost over time due to the …
The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight
INTRODUCTION To date, 559 humans have been flown into space, but long-duration (> 300
days) missions are rare (n= 8 total). Long-duration missions that will take humans to Mars …
days) missions are rare (n= 8 total). Long-duration missions that will take humans to Mars …
Measurement and initial characterization of leukocyte telomere length in 474,074 participants in UK Biobank
Leukocyte telomere length (LTL) is a proposed marker of biological age. Here we report the
measurement and initial characterization of LTL in 474,074 participants in UK Biobank. We …
measurement and initial characterization of LTL in 474,074 participants in UK Biobank. We …
Transcriptional and epigenetic decoding of the microglial aging process
As important immune cells, microglia undergo a series of alterations during aging that
increase the susceptibility to brain dysfunctions. However, the longitudinal characteristics of …
increase the susceptibility to brain dysfunctions. However, the longitudinal characteristics of …
Identification of seven loci affecting mean telomere length and their association with disease
Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …
and several age-associated diseases. We report here a genome-wide meta-analysis of …
Comparison of telomere length measurement methods
The strengths and limitations of the major methods developed to measure telomere lengths
(TLs) in cells and tissues are presented in this review. These include Q-PCR (Q uantitative P …
(TLs) in cells and tissues are presented in this review. These include Q-PCR (Q uantitative P …
Telomere length in epidemiology: a biomarker of aging, age-related disease, both, or neither?
JL Sanders, AB Newman - Epidemiologic reviews, 2013 - academic.oup.com
Telomeres are nucleoprotein caps flanking DNA. They are shortened by cell division and
oxidative stress and are lengthened by the enzyme telomerase and DNA exchange during …
oxidative stress and are lengthened by the enzyme telomerase and DNA exchange during …
Genome-wide association analysis in humans links nucleotide metabolism to leukocyte telomere length
C Li, S Stoma, LA Lotta, S Warner, E Albrecht… - The American Journal of …, 2020 - cell.com
Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we
perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed …
perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed …