Therapeutic strategies to overcome taxane resistance in cancer
One of the primary causes of attenuated or loss of efficacy of cancer chemotherapy is the
emergence of multidrug resistance (MDR). Numerous studies have been published …
emergence of multidrug resistance (MDR). Numerous studies have been published …
Current advances of tubulin inhibitors as dual acting small molecules for cancer therapy
KE Arnst, S Banerjee, H Chen, S Deng… - Medicinal research …, 2019 - Wiley Online Library
Microtubule (MT)‐targeting agents are highly successful drugs as chemotherapeutic agents,
and this is attributed to their ability to target MT dynamics and interfere with critical cellular …
and this is attributed to their ability to target MT dynamics and interfere with critical cellular …
Isolation, characterization, anti-MRSA evaluation, and in-silico multi-target anti-microbial validations of actinomycin X2 and actinomycin D produced by novel …
KA Qureshi, AD Bholay, PK Rai, HA Mohammed… - Scientific reports, 2021 - nature.com
Streptomyces smyrnaeus UKAQ_23, isolated from the mangrove-sediment, collected from
Jubail, Saudi Arabia, exhibited substantial antimicrobial activity against methicillin-resistant …
Jubail, Saudi Arabia, exhibited substantial antimicrobial activity against methicillin-resistant …
NMR as a “gold standard” method in drug design and discovery
Studying disease models at the molecular level is vital for drug development in order to
improve treatment and prevent a wide range of human pathologies. Microbial infections are …
improve treatment and prevent a wide range of human pathologies. Microbial infections are …
Emerging status of multidrug-resistant bacteria and fungi in the arabian peninsula
Simple Summary The incidence and developing status of multidrug-resistant bacteria and
fungi, as well as their related mortality, is reviewed by a systematic published literature …
fungi, as well as their related mortality, is reviewed by a systematic published literature …
[HTML][HTML] Resistance to anti-tubulin agents: From vinca alkaloids to epothilones
W Krause - Cancer Drug Resistance, 2019 - ncbi.nlm.nih.gov
This review describes the mechanism of action-inhibition of microtubules-and the most
important mechanisms of resistance for vinca alkaloids, taxanes and epothilones …
important mechanisms of resistance for vinca alkaloids, taxanes and epothilones …
Synthesis and evaluation of novel α-substituted chalcones with potent anti-cancer activities and ability to overcome multidrug resistance
A series of forty α-substituted chalcones were synthesized and screened for their
antiproliferative activities against HCT116 (colorectal) and HCC1954 (breast) cancer cell …
antiproliferative activities against HCT116 (colorectal) and HCC1954 (breast) cancer cell …
Design, synthesis, and biological evaluation of SSE1806, a microtubule destabilizer that overcomes multidrug resistance
Microtubules are dynamic structures that form spindle fibers during cell division;
pharmacological inhibition of microtubule dynamics arrests cells in mitosis, leading to …
pharmacological inhibition of microtubule dynamics arrests cells in mitosis, leading to …
Light-induced stabilization of microtubules by photo-crosslinking of a Tau-derived peptide
For light-induced stabilization of microtubules (MTs) to manipulate cells, a photo-reactive
diazirine group was conjugated to a Tau-derived peptide, a motif binding on the inside of …
diazirine group was conjugated to a Tau-derived peptide, a motif binding on the inside of …
Natural and semisynthetic chalcones as dual FLT3 and microtubule polymerization inhibitors
Activating mutations in FLT3 receptor tyrosine kinase are found in a third of acute myeloid
leukemia (AML) patients and are associated with disease relapse and a poor prognosis. The …
leukemia (AML) patients and are associated with disease relapse and a poor prognosis. The …