Immunogenic cell death activates the tumor immune microenvironment to boost the immunotherapy efficiency

Z Li, X Lai, S Fu, L Ren, H Cai, H Zhang, Z Gu… - Advanced …, 2022 - Wiley Online Library
Tumor immunotherapy is only effective in a fraction of patients due to a low response rate
and severe side effects, and these challenges of immunotherapy in clinics can be addressed …

Tumor abnormality-oriented nanomedicine design

Q Zhou, J Xiang, N Qiu, Y Wang, Y Piao, S Shao… - Chemical …, 2023 - ACS Publications
Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy

Q Zhou, S Shao, J Wang, C Xu, J Xiang, Y Piao… - Nature …, 2019 - nature.com
A tumour microenvironment imposes barriers to the passive diffusion of molecules, which
renders tumour penetration an unresolved obstacle to an effective anticancer drug delivery …

Dependence of nanoparticle toxicity on their physical and chemical properties

A Sukhanova, S Bozrova, P Sokolov… - Nanoscale research …, 2018 - Springer
Studies on the methods of nanoparticle (NP) synthesis, analysis of their characteristics, and
exploration of new fields of their applications are at the forefront of modern nanotechnology …

[HTML][HTML] A systematic review on silver nanoparticles-induced cytotoxicity: Physicochemical properties and perspectives

M Akter, MT Sikder, MM Rahman, AKMA Ullah… - Journal of advanced …, 2018 - Elsevier
With the development of nanotechnology, silver nanoparticles (Ag-NPs) have become one
of the most in-demand nanoparticles owing to their exponential number of uses in various …

Stimuli‐Responsive antibacterial materials: molecular structures, design principles, and biomedical applications

X Wang, M Shan, S Zhang, X Chen, W Liu… - Advanced …, 2022 - Wiley Online Library
Infections are regarded as the most severe complication associated with human health,
which are urgent to be solved. Stimuli‐responsive materials are appealing therapeutic …

Recent advances in active targeting of nanomaterials for anticancer drug delivery

B Dutta, KC Barick, PA Hassan - Advances in colloid and interface science, 2021 - Elsevier
One of the challenges in cancer chemotherapy is the low target to non-target ratio of
therapeutic agents which incur severe adverse effect on the healthy tissues. In this regard …

Rational design of cancer nanomedicine: nanoproperty integration and synchronization

Q Sun, Z Zhou, N Qiu, Y Shen - Advanced materials, 2017 - Wiley Online Library
Current cancer nanomedicines can only mitigate adverse effects but fail to enhance
therapeutic efficacies of anticancer drugs. Rational design of next‐generation cancer …

Effect of physicochemical and surface properties on in vivo fate of drug nanocarriers

Z Zhao, A Ukidve, V Krishnan, S Mitragotri - Advanced drug delivery …, 2019 - Elsevier
Over the years, a plethora of materials–natural and synthetic–have been engineered at a
nanoscopic level and explored for drug delivery. Nanocarriers based on such materials …

Good steel used in the blade: well‐tailored type‐I photosensitizers with aggregation‐induced emission characteristics for precise nuclear targeting photodynamic …

M Kang, Z Zhang, W Xu, H Wen, W Zhu… - Advanced …, 2021 - Wiley Online Library
Photodynamic therapy (PDT) has long been recognized to be a promising approach for
cancer treatment. However, the high oxygen dependency of conventional PDT dramatically …