The ability to observe cells in live organisms is essential for understanding their function in
complex in vivo milieus. A major challenge today has been the limited ability to perform …

Assessing programmed death ligand 1 (PD-L1) expression through immunohistochemistry
(IHC) is the golden standard in predicting immunotherapy response of non-small cell lung …

Aberrations limit scanning fluorescence microscopy when imaging in scattering materials
such as biological tissue. Model-based approaches for adaptive optics take advantage of a …

Imaging flow cytometry (FC) is a powerful analytic tool that combines the principles of
conventional FC with rich spatial information, allowing more profound insight into single-cell …

Recent advances in biochemistry and optics have enabled observation of the faintest
signals from even single molecules. However, although biological samples can have …

In the frequency domain semi‐airborne electromagnetic detection method, the receiving
signal from the coil sensor contains a quantity of noise. In order to improve signal‐to‐noise …

Optical neuronal imaging often shows ultrafine structures, such as a nerve fiber, coexisting
with ultrabright structures, such as a soma with a substantially higher fluorescence-protein …

Gene transcription is an essential process in cell biology, and allows cells interpret and
respond to internal and external cues. Traditional bulk population methods (Northern blot …

Structured illumination microscope (SIM) can double the spatial resolution by using fringed
pattern illumination. However, for samples with large intra-scene dynamic ranges, such as …

Understanding the spatial distribution of key cell populations is critical in advancing
biomedical research and the development of novel therapeutics. Highly multiplexed …