Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …

Fibroblastic stromal cells are as diverse, in origin and function, as the niches they fashion in
the mammalian body. This cellular variety impacts the spectrum of responses elicited by the …

Aging is associated with impaired hematopoietic and immune function caused in part by
decreased fitness in the hematopoietic stem cell (HSC) population and an increased …

Despite our growing understanding of embryonic immune development, rare early
megakaryocytes (MKs) remain relatively understudied. Here we used single-cell RNA …

Hematopoietic stem cells (HSCs) are the life-long source of all types of blood cells. Their
function is controlled by their direct microenvironment, the HSC niche in the bone marrow …

Cellular quiescence is a dormant but reversible cellular state in which cell-cycle entry and
proliferation are prevented. Recent studies both in vivo and in vitro demonstrate that …

Long-term hematopoietic stem cells (LT-HSCs) maintain hematopoietic output throughout an
animal's lifespan. However, with age, the balance is disrupted, and LT-HSCs produce a …

Hematopoietic stem cells (HSC) are responsible for the production of mature blood cells. To
ensure that the HSC pool does not get exhausted over the lifetime of an individual, most …

Abstract Extracellular matrix protein 1 (ECM1) is related to strong invasiveness and poor
prognosis in major malignancies, but the underlying mechanism remains unknown. Here we …

Designing chiral materials to manipulate the biological activities of cells has been an
important area not only in chemistry and material science, but also in cell biology and …