Objective High-grade aneuploidies of X and Y sex chromosomes (HGAs) are exceedingly
rare and complex conditions. We aimed to investigate the effect of supernumerary X …

Microcirculation is pervasive and orchestrates a profound regulatory cross-talk with the
surrounding tissue and organs. Similarly, it is one of the earliest biological systems targeted …

Rationale: Azoospermia is a significant reproductive challenge. Differentiating between non-
obstructive azoospermia (NOA) and obstructive azoospermia (OA) is crucial as each type …

Objective Klinefelter syndrome is the most common chromosomal disorder in males and the
most common cause of hypergonadotropic hypogonadism. We describe the natural history …

Abstract STUDY QUESTION Does Klinefelter syndrome (KS) lead to a distinct gene
expression pattern at single-cell level in the testes that could provide insight into the …

To present the results of testicular ultrasonography supported by clinical and hormonal
aspects in paediatric patients with Klinefelter syndrome (KS). Prospective analysis of …

Background Bilateral testicular germ cell tumours (B‐GCT) are rare, with an incidence of 2–
5%, and can be classified as synchronous (sB‐GCT) or metachronous (mB‐GCT). Our study …

Background The relationship between microcirculatory disorders and testicular
spermatogenesis is an area of ongoing interest among urologists. The objective of this …

Introduction. To investigate the predictive factors for successful repeat microdissection
testicular sperm extraction attempts in patients with Klinefelter syndrome. Methods. A total of …

KS was first documented in 1942 by Dr. Harry Klinefelter. He described men with
gynecomastia and a very specific type of hypogonadism (58). Seventeen years later, Jacobs …