Motile cells have developed a variety of migration modes relying on diverse traction-force-
generation mechanisms. Before the behavior of intracellular components could be easily …

In recent years experiments have demonstrated that living cells can measure low chemical
concentrations with high precision, and much progress has been made in understanding …

Cell migration is hypothesized to involve a cycle of behaviours beginning with leading edge
extension. However, recent evidence suggests that the leading edge may be dispensable …

What is the underlying diffusion process governing the spreading dynamics and search
strategies employed by amoeboid cells? Based on the statistical analysis of experimental …

For a general sensory system following an external stochastic signal, we introduce the
sensory capacity. This quantity characterizes the performance of a sensor: sensory capacity …

An essential ability of many cell types is to detect stimuli in the form of shallow chemical
gradients. Such cues may indicate the direction that new growth should occur, or the …

Biology is data-rich, and it is equally rich in concepts and hypotheses. Part of trying to
understand biological processes and systems is therefore to confront our ideas and …

Living cells can enhance their fitness by anticipating environmental change. We study how
accurately linear signaling networks in cells can predict future signals. We find that maximal …

The chemotactic network of Escherichia coli has been studied extensively both biophysically
and information theoretically. Nevertheless, connection between these two aspects is still …

Many types of cells require the ability to pinpoint the location of an external stimulus from the
arrival of diffusing signaling molecules at cell-surface receptors. How does the organization …