Spatially resolved mass spectrometry at the single cell: recent innovations in proteomics and metabolomics
MJ Taylor, JK Lukowski… - Journal of the American …, 2021 - ACS Publications
Biological systems are composed of heterogeneous populations of cells that
intercommunicate to form a functional living tissue. Biological function varies greatly across …
intercommunicate to form a functional living tissue. Biological function varies greatly across …
[HTML][HTML] Mass spectrometry imaging: a review of emerging advancements and future insights
Mass spectrometry imaging (MSI) is a powerful tool that enables untargeted investigations
into the spatial distribution of molecular species in a variety of samples. It has the capability …
into the spatial distribution of molecular species in a variety of samples. It has the capability …
Ambient ionization mass spectrometry: recent developments and applications
The early 2000s brought a new age in the field of mass spectrometry (MS) with the
introduction of ambient ionization MS techniques. As defined by one of its early visionaries …
introduction of ambient ionization MS techniques. As defined by one of its early visionaries …
High spatial resolution imaging of biological tissues using nanospray desorption electrospray ionization mass spectrometry
Mass spectrometry imaging (MSI) enables label-free spatial mapping of hundreds of
biomolecules in tissue sections. This capability provides valuable information on tissue …
biomolecules in tissue sections. This capability provides valuable information on tissue …
Emerging computational methods in mass spectrometry imaging
Mass spectrometry imaging (MSI) is a powerful analytical technique that generates maps of
hundreds of molecules in biological samples with high sensitivity and molecular specificity …
hundreds of molecules in biological samples with high sensitivity and molecular specificity …
Concepts and methods to access novel antibiotics from actinomycetes
Actinomycetes have been proven to be an excellent source of secondary metabolites for
more than half a century. Exhibiting various bioactivities, they provide valuable approved …
more than half a century. Exhibiting various bioactivities, they provide valuable approved …
High throughput reaction screening using desorption electrospray ionization mass spectrometry
We report the high throughput analysis of reaction mixture arrays using methods and data
handling routines that were originally developed for biological tissue imaging. Desorption …
handling routines that were originally developed for biological tissue imaging. Desorption …
Imaging and analysis of isomeric unsaturated lipids through online photochemical derivatization of carbon–carbon double bonds
Unraveling the complexity of the lipidome requires the development of novel approaches for
the structural characterization of lipid species with isomer‐level discrimination. Herein, we …
the structural characterization of lipid species with isomer‐level discrimination. Herein, we …
High-resolution imaging and identification of biomolecules using Nano-DESI coupled to ion mobility spectrometry
Simultaneous spatial localization and structural characterization of molecules in complex
biological samples currently represents an analytical challenge for mass spectrometry …
biological samples currently represents an analytical challenge for mass spectrometry …
High-throughput Nano-DESI mass spectrometry imaging of biological tissues using an integrated microfluidic probe
Nanospray desorption electrospray mass spectrometry imaging (nano-DESI MSI) enables
quantitative mapping of hundreds of molecules in biological samples with minimal sample …
quantitative mapping of hundreds of molecules in biological samples with minimal sample …