Metastasis is the leading cause of cancer mortality. The metastatic cascade represents a
multi-step process which includes local tumor cell invasion, entry into the vasculature …

The possibility of safe discontinuation of therapy with nucleos (t) ide analogues (NAs)
remains one of the most controversial topics in the management of chronic hepatitis B …

Despite progress in the diagnostics and treatment of hepatocellular carcinoma (HCC), its
prognosis remains poor. In this study, we globally assessed long noncoding RNAs (lncRNA) …

Hepatocellular Carcinoma (HCC) is one of the most common malignant tumours in the
world. It is a heterogeneous group of a tumour that vary in risk factor and genetic and …

Malignant carcinomas are often characterized by metastasis, the movement of carcinoma
cells from a primary site to colonize distant organs. For metastasis to occur, carcinoma cells …

Recent developments indicate that macrodomains, an ancient and diverse protein domain
family, are key players in the recognition, interpretation, and turnover of ADP-ribose (ADPr) …

Background & Aims Tumor resistance to radiation is a challenge in the treatment of patients
with pancreatic cancer. Improving our understanding of the mechanisms of radioresistance …

Hepatocellular carcinoma (HCC) is the most common primary malignant tumor that accounts
for~ 80% of all liver cancer cases worldwide. It is a multifactorial disease caused by a variety …

Abstract The Rho family of GTPases represents a class of Ras-related signaling molecules
often deregulated in cancer. Rho GTPases switch from a GDP-bound, inactive state to a GTP …

Previous studies have demonstrated that microRNA (miRNA) expression is altered in human
cancer. However, the molecular mechanism underlying these changes in miRNA expression …