What animal models can tell us about long-term cognitive dysfunction following sepsis: a systematic review

FF Savi, A de Oliveira, GF de Medeiros… - Neuroscience & …, 2021 - Elsevier
Survivors of sepsis often develop long-term cognitive impairments. This review aimed at
exploring the results of the behavioral tools and tests which have been used to evaluate …

Delayed effects of neonatal immune activation on brain neurochemistry and hypothalamic–pituitary–adrenal axis functioning

JN Khantakova, NP Bondar… - European Journal of …, 2022 - Wiley Online Library
During the postnatal period, the brain is highly sensitive to stress and inflammation, which
are hazardous to normal growth and development. There is increasing evidence that …

Infection, learning, and memory: Focus on immune activation and aversive conditioning

IR Bishnoi, CJ Cloutier, CD Tyson, VM Matic… - Neuroscience & …, 2022 - Elsevier
Here we review the effects of immune activation primarily via lipopolysaccharide (LPS), a
cell wall component of Gram-negative bacteria, on hippocampal and non-hippocampal …

Analysis of differentially expressed genes in the dentate gyrus and anterior cingulate cortex in a mouse model of depression

Y Wei, K Qi, Y Yu, W Lu, W Xu… - BioMed Research …, 2021 - Wiley Online Library
Major depressive disorder (MDD) is a prevalent, chronic, and relapse‐prone psychiatric
disease. However, the intermediate molecules resulting from stress and neurological …

Exposure to bacterial lipopolysaccharide in early life affects the expression of ionotropic glutamate receptor genes and is accompanied by disturbances in long-term …

OE Zubareva, TY Postnikova, AV Grifluk… - Brain, Behavior, and …, 2020 - Elsevier
Infections in childhood play an essential role in the pathogenesis of cognitive and psycho-
emotional disorders. One of the possible mechanisms of these impairments is changes in …

Neonatal lipopolysaccharide challenge induces long-lasting spatial cognitive impairment and dysregulation of hippocampal histone acetylation in mice

L Peng, M Zhu, Y Yang, Y Weng, W Zou, X Zhu, Q Guo… - Neuroscience, 2019 - Elsevier
Neonatal inflammation induces long-term effects on brain function. We investigated the
effects of systematic neonatal inflammation using lipopolysaccharide (LPS) injection at …

Molecular and behavioural abnormalities in the FUS‐tg mice mimic frontotemporal lobar degeneration: Effects of old and new anti‐inflammatory therapies

J de Munter, D Babaevskaya… - Journal of Cellular …, 2020 - Wiley Online Library
Genetic mutations in FUS, a DNA/RNA‐binding protein, are associated with inherited forms
of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). A …

[HTML][HTML] Unveiling the Mechanisms of a Remission in Major Depressive Disorder (MDD)-like Syndrome: The Role of Hippocampal Palmitoyltransferase Expression …

CA Schroeter, A Gorlova, M Sicker, A Umriukhin… - …, 2025 - pmc.ncbi.nlm.nih.gov
Post-translational modifications of proteins via palmitoylation, a thioester linkage of a 16-
carbon fatty acid to a cysteine residue, reversibly increases their affinity for cholesterol-rich …

Short-and long-term cognitive and metabolic effects of medium-chain triglyceride supplementation in rats

K Shcherbakova, A Schwarz, I Ivleva, V Nikitina… - Heliyon, 2023 - cell.com
Medium-chain triglycerides (MCT) possess neuroprotective properties. However, the long-
term metabolic consequences of supplementing a regular diet with cognition-enhancing …

Bodyweight, locomotion, and behavioral responses of the naked mole rat (Heterocephalus glaber) to lipopolysaccharide administration

ML Kisipan, RO Ojoo, TI Kanui… - Journal of Comparative …, 2022 - Springer
The naked mole rat has unique biologic characteristics that include atypical inflammatory
responses. Lipopolysaccharide induces inflammation which triggers brain centers …