Enzymatically oxidized lipids are a specific group of biomolecules that function as key
signaling mediators and hormones, regulating various cellular and physiological processes …

Polyunsaturated fatty acids (PUFA) are oxidized by cytochrome P450 epoxygenases to
PUFA epoxides which function as potent lipid mediators. The major metabolic pathways of …

The discovery of the cannabinoid receptors CB1 and CB2 in 19881, 2 and 1990, 3
respectively, and of the endogenous cannabinoid ligands (endocannabinoids) …

In the last few decades, endocannabinoids, plant-derived cannabinoids and synthetic
cannabinoids have received growing interest as treatment options in neurodegenerative …

Polymorphic drug-metabolizing enzymes (DMEs) are responsible for the metabolism of the
majority of psychotropic drugs. By explaining a large portion of variability in individual drug …

Abstract The endocannabinoids 2-arachidonoyl-glycerol (2-AG) and N-arachidonoyl-
ethanolamine (AEA) are eicosanoids implicated in numerous physiological processes like …

Epilepsy is a neurological disorder that affects approximately 50 million people worldwide.
There is currently no definitive epilepsy cure. However, in recent years, medicinal cannabis …

The naturally occurring mammalian endocannabinoids possess biological attributes that
extend beyond interaction with cannabinoid receptors. These extended biological properties …

Significance: Redox imbalance may lead to overproduction of reactive oxygen and nitrogen
species (ROS/RNS) and subsequent oxidative tissue damage, which is a critical event in the …

Cytochrome P450 enzymes (CYPs) metabolize many drugs that act on the central nervous
system (CNS), such as antidepressants and antipsychotics; drugs of abuse; endogenous …