Brain cell structure is a key determinant of neural function that is frequently altered in
neurobiological disorders. Following the global loss of blood flow to the brain that initiates …

Tauopathies are a category of neurodegenerative diseases characterized by the presence
of abnormal tau protein-containing neurofibrillary tangles (NFTs). NFTs are universally …

In the coming years, artificial intelligence (AI) and machine learning will likely give rise to
profound changes in the field of emergency medicine, and medicine more broadly. This …

Neuropathologic assessment during autopsy is the gold standard for diagnosing
neurodegenerative disorders. Neurodegenerative conditions, such as Alzheimer disease …

Understanding age acceleration, the discordance between biological and chronological
age, in the brain can reveal mechanistic insights into normal physiology as well as elucidate …

Digital pathology (DP) has transformative potential, especially for Alzheimer disease and
related disorders. However, infrastructure barriers may limit adoption. To provide …

High-throughput digital pathology offers considerable advantages over traditional
semiquantitative and manual methods of counting pathology. We used brain tissue from 5 …

Computational machine learning (ML)-based frameworks could be advantageous for
scalable analyses in neuropathology. A recent deep learning (DL) framework has shown …

Introducing interpretability and reasoning into Multiple Instance Learning (MIL) methods for
Whole Slide Image (WSI) analysis is challenging given the complexity of gigapixel slides …

Artificial Intelligence (AI), which is the general term used to describe technology that
simulates human cognition [1], has taken on a prominent role in twenty-first-century clinical …