Targeting proteases in cystic fibrosis lung disease. Paradigms, progress, and potential

MC McKelvey, S Weldon, DF McAuley… - American Journal of …, 2020 - atsjournals.org
Cystic fibrosis (CF) is an autosomal recessive genetic condition, predominantly of white
populations, that impacts multiple organ systems. However, it is the chronic progressive lung …

Stenotrophomonas maltophilia virulence: a current view

V Mikhailovich, R Heydarov, D Zimenkov… - Frontiers in …, 2024 - frontiersin.org
Stenotrophomonas maltophilia is an opportunistic pathogen intrinsically resistant to multiple
and broad-spectrum antibiotics. Although the bacterium is considered a low-virulence …

A Stenotrophomonas maltophilia TetR-like transcriptional regulator involved in fatty acid metabolism is controlled by quorum sensing signals

X Coves, M Bravo, P Huedo… - Applied and …, 2023 - Am Soc Microbiol
Stenotrophomonas maltophilia is an environmental bacterium as well as an emerging
opportunistic multidrug-resistant pathogen. They use the endogenous diffusible signal factor …

Bacterial interference with lactate dehydrogenase assay leads to an underestimation of cytotoxicity

S Van den Bossche, E Vandeplassche… - Frontiers in Cellular …, 2020 - frontiersin.org
Models to study host-pathogen interactions in vitro are an important tool for investigating the
infectious disease process and evaluating the efficacy of antimicrobial compounds. In these …

Effect of Soaking and Proteolytic Microorganisms Growth on the Protein and Amino Acid Content of Jack Bean Tempeh (Canavalia ensiformis)

VP Yarlina, M Djali, R Andoyo, MN Lani, M Rifqi - Processes, 2023 - mdpi.com
Soaking is an important step in making tempeh. Tempeh fermentation normally involves the
natural presence of proteolytic bacteria capable of producing protease enzymes to break …

Study of nano-hydroxyapatite tagged alkaline protease isolated from Himalayan sub-alpine Forest soil bacteria and role in recalcitrant feather waste degradation

S Sengupta, P Basak, P Ghosh, A Pramanik… - International Journal of …, 2023 - Elsevier
Purified calcium serine metalloprotease from Stenotrophomonas maltophilia strain SMPB12
exhibits highest enzyme activity at pH 9 and temperature range between 15° C–25° C …

Antibacterial and Antivirulence Activity of Glucocorticoid PYED-1 against Stenotrophomonas maltophilia

A Esposito, A Vollaro, EP Esposito, D D'Alonzo… - Antibiotics, 2020 - mdpi.com
Stenotrophomonas maltophilia, an environmental Gram-negative bacterium, is an emerging
nosocomial opportunistic pathogen that causes life-threatening infections in …

Co-regulation of Thermosensor Pathogenic Factors by C-di-GMP-Related Two-Component Systems and a cAMP Receptor-like Protein (Clp) in Stenotrophomonas …

J Ding, M Liao, Q Wang - Foods, 2024 - mdpi.com
Stenotrophomonas maltophilia is a major threat to the food industry and human health
owing to its strong protease production and biofilm formation abilities. However, information …

Impaired Airway Epithelial Barrier Integrity in Response to Stenotrophomonas maltophilia Proteases, Novel Insights Using Cystic Fibrosis Bronchial Epithelial Cell …

K Molloy, G Cagney, ET Dillon, K Wynne… - Frontiers in …, 2020 - frontiersin.org
Stenotrophomonas maltophilia is a Gram-negative opportunistic pathogen that can
chronically colonize the lungs of people with cystic fibrosis (CF) and is associated with lethal …

Epithelial damage in the cystic fibrosis lung: the role of host and microbial factors

AMA Glasgow, CM Greene - Expert Review of Respiratory …, 2022 - Taylor & Francis
Introduction The airway epithelium is a key system within the lung. It acts as a physical
barrier to inhaled factors, and can actively remove unwanted microbes and particles from the …