E3 ubiquitin ligases are a large family of enzymes that join in a three-enzyme ubiquitination
cascade together with ubiquitin activating enzyme E1 and ubiquitin conjugating enzyme E2 …

Protein ubiquitination is a dynamic multifaceted post-translational modification involved in
nearly all aspects of eukaryotic biology. Once attached to a substrate, the 76-amino acid …

Ubiquitin plays an essential role in modulating protein functions, and deregulation of the
ubiquitin system leads to the development of multiple human diseases. Owing to its …

Homologous recombination (HR) is a major pathway for the repair of DNA double-strand
breaks in mammalian cells, the defining step of which is homologous strand exchange …

DNA double-strand breaks (DSBs) are highly toxic lesions that can drive genetic instability.
To preserve genome integrity, organisms have evolved several DSB repair mechanisms, of …

Protein ubiquitination has become one of the most extensively studied post-translational
modifications. Originally discovered as a critical element in highly regulated proteolysis …

DNA double-strand breaks (DSBs) are highly cytotoxic DNA lesions. The swift recognition
and faithful repair of such damage is crucial for the maintenance of genomic stability, as well …

The ability of ubiquitin to form up to eight different polyubiquitin chain linkages generates
complexity within the ubiquitin proteasome system, and accounts for the diverse roles of …

Ubiquitylation is one of the most abundant and versatile post-translational modifications
(PTMs) in cells. Its versatility arises from the ability of ubiquitin to form eight structurally and …

Protein ubiquitination and protein phosphorylation are two fundamental regulatory post-
translational modifications controlling intracellular signalling events. However, the ubiquitin …