Anesthesia and developing brains: unanswered questions and proposed paths forward

C Ing, DO Warner, LS Sun, RP Flick… - Obstetric Anesthesia …, 2022 - journals.lww.com
Optimizing surgical technique is an important part of improving outcomes in cesarean
delivery. It is unclear whether uterine exteriorization is associated with hemostasis benefits …

Does general anesthesia affect neurodevelopment in infants and children?

ME McCann, SG Soriano - Bmj, 2019 - bmj.com
General anesthesia has been unequivocally linked to abnormal development of the central
nervous system, leading to neurocognitive impairments in laboratory models. In vitro and in …

Preoperative fluid fasting times and postinduction low blood pressure in children: a retrospective analysis

AF Simpao, L Wu, O Nelson, JA Gálvez, JM Tan… - …, 2020 - ingentaconnect.com
Background: Children are required to fast before elective general anesthesia. This study
hypothesized that prolonged fasting causes volume depletion that manifests as low blood …

Isoelectric electroencephalography in infants and toddlers during anesthesia for surgery: an international observational study

I Yuan, T Xu, J Skowno, B Zhang, A Davidson… - …, 2022 - ingentaconnect.com
Background: Intraoperative isoelectric electroencephalography (EEG) has been associated
with hypotension and postoperative delirium in adults. This international prospective …

A practical approach to cerebral near‐infrared spectroscopy (NIRS) directed hemodynamic management in noncardiac pediatric anesthesia

F Weber, GP Scoones - Pediatric Anesthesia, 2019 - Wiley Online Library
Safeguarding cerebral function is of major importance during pediatric anesthesia.
Premature, ex‐premature, and full‐term neonates can be vulnerable to physiological …

[HTML][HTML] Postoperative kidney oxygen saturation as a novel marker for acute kidney injury after adult cardiac surgery

C Ortega-Loubon, M Fernández-Molina, I Fierro… - The Journal of Thoracic …, 2019 - Elsevier
Objective Acute kidney injury is a severe complication and one of the stronger risk factors for
death in patients undergoing cardiac surgery. The relationship between postoperative brain …

Beyond anesthesia toxicity: anesthetic considerations to lessen the risk of neonatal neurological injury

ME McCann, JK Lee, T Inder - Anesthesia & Analgesia, 2019 - journals.lww.com
Infants who undergo surgical procedures in the first few months of life are at a higher risk of
death or subsequent neurodevelopmental abnormalities. Although the pathogenesis of …

Near-infrared spectroscopy monitoring in cardiac and noncardiac surgery: pairwise and network meta-analyses

C Ortega-Loubon, F Herrera-Gómez… - Journal of clinical …, 2019 - mdpi.com
Goal-directed therapy based on brain-oxygen saturation (bSo2) is controversial and hotly
debated. While meta-analyses of aggregated data have shown no clinical benefit for brain …

Development of a nomogram to predict negative postoperative behavioral changes based on a prospective cohort

L Li, J Zhang, J Li, Y Ren, Z Gao, J Gao, F Zhang… - BMC …, 2023 - Springer
Background It is believed that negative postoperative behavioral changes (NPOBC) is
associated with negative perioperative outcomes in children. The importance of …

Using electroencephalography (EEG) to guide propofol and sevoflurane dosing in pediatric anesthesia

I Yuan, T Xu, CD Kurth - Anesthesiology clinics, 2020 - anesthesiology.theclinics.com
Inhaled sevoflurane and intravenous (IV) propofol are 2 of the primary drugs used to
anesthetize children. Dosing for these agents is guided by monitoring expired concentration …