Specification and role of extraembryonic endoderm lineages in the periimplantation mouse embryo

K Filimonow, R de la Fuente - Theriogenology, 2022 - Elsevier
During mammalian embryo development, the correct formation of the first extraembryonic
endoderm lineages is fundamental for successful development. In the periimplantation …

[PDF][PDF] SyNPL: Synthetic Notch pluripotent cell lines to monitor and manipulate cell interactions in vitro and in vivo

M Malaguti, R Portero Migueles, J Annoh… - …, 2022 - journals.biologists.com
Cell-cell interactions govern differentiation and cell competition in pluripotent cells during
early development, but the investigation of such processes is hindered by a lack of efficient …

Comparing AI versus Optimization Workflows for Simulation-Based Inference of Spatial-Stochastic Systems

MA Ramirez Sierra, T Sokolowski - Machine Learning: Science …, 2024 - iopscience.iop.org
Abstract Model parameter inference is a universal problem across science. This challenge is
particularly pronounced in developmental biology, where faithful mechanistic descriptions …

Tissues as networks of cells: towards generative rules of complex organ development

SC Fischer, GW Bassel… - Journal of the Royal …, 2023 - royalsocietypublishing.org
Network analysis is a well-known and powerful tool in molecular biology. More recently, it
has been introduced in developmental biology. Tissues can be readily translated into spatial …

AI-powered simulation-based inference of a genuinely spatial-stochastic gene regulation model of early mouse embryogenesis

MA Ramirez Sierra, TR Sokolowski - PLOS Computational Biology, 2024 - journals.plos.org
Understanding how multicellular organisms reliably orchestrate cell-fate decisions is a
central challenge in developmental biology, particularly in early mammalian development …

El patrón de sal y pimienta en los blastocistos de ratón es compatible con la señalización más allá de los vecinos más cercanos

SC Fischer, S Schardt, J Lilao Garzón… - Iscience, 2023 - accedacris.ulpgc.es
Los embriones se desarrollan en una secuencia concertada de disposiciones
espaciotemporales de células. En el embrión de ratón previo a la implantación, la …

A toolkit for mapping cell identities in relation to neighbours reveals Notch-dependent heterogeneity within neuromesodermal progenitor populations

M French, R Portero Migueles, JK Dale, G Blin… - bioRxiv, 2024 - biorxiv.org
Patterning of cell fates is central to embryonic development, tissue homeostasis, and
disease. Quantitative analysis of patterning reveals the logic by which cell-cell interactions …

insideOutside: an accessible algorithm for classifying interior and exterior points, with applications in embryology

SE Strawbridge, A Kurowski, E Corujo-Simon… - Biology …, 2023 - journals.biologists.com
ABSTRACT A crucial aspect of embryology is relating the position of individual cells to the
broader geometry of the embryo. A classic example of this is the first cell-fate decision of the …

Unlabelled landmark matching via Bayesian data selection, and application to cell matching across imaging modalities

JE Forsyth, AH Al-Anbaki, B Plusa, SL Cotter - Statistics and Computing, 2023 - Springer
We consider the problem of landmark matching between two unlabelled point sets, in
particular where the number of points in each cloud may differ, and where points in each …

The salt-and-pepper pattern in mouse blastocysts is compatible with signaling beyond the nearest neighbors

SC Fischer, S Schardt, J Lilao-Garzón… - Iscience, 2023 - cell.com
Embryos develop in a concerted sequence of spatiotemporal arrangements of cells. In the
preimplantation mouse embryo, the distribution of the cells in the inner cell mass evolves …