This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

A growing body of data supports a view of the actin cytoskeleton of smooth muscle cells as a
dynamic structure that plays an integral role in regulating the development of mechanical …

The potent vasodilator action of cyclic GMP-dependent protein kinase (cGK) involves
decreasing the Ca 2+ sensitivity of contraction of smooth muscle via stimulation of myosin …

Signaling through G protein-coupled receptors (GPCRs) mediates numerous airway smooth
muscle (ASM) functions including contraction, growth, and" synthetic" functions that …

Morphological, functional, molecular and cell biology studies have revealed a striking
multifunctional nature of individual smooth muscle cells (SMC). SMCs manifest phenotypic …

Normal physiological voiding as well as generation of abnormal bladder contractions in
diseased states is critically dependent on acetylcholine-induced stimulation of contractile …

Smooth muscle cells are able to adapt rapidly to chemical and mechanical signals
impinging on the cell surface. It has been suggested that dynamic changes in the actin …

Evidence supporting the functionality of Smoothened (SMO), an essential transducer in most
pathways engaged by Hedgehog (Hh), as a G i-coupled receptor contrasts with the lack of …

Muscarinic acetylcholine receptor subtypes have been the subjects of research for at least a
quarter of a century. Nonetheless, there are few selective muscarinic receptor ligands …

Signaling pathways for muscarinic acetylcholine receptors (mAChRs) include several
enzymes and ion channels. Recent studies have revealed the importance of various …