B cells and antibodies in multiple sclerosis pathogenesis and therapy

M Krumbholz, T Derfuss, R Hohlfeld… - Nature Reviews …, 2012 - nature.com
B cells and antibodies account for the most prominent immunodiagnostic feature in patients
with multiple sclerosis (MS), namely oligoclonal bands. Furthermore, evidence is …

Cigarette smoking differentially affects immunoglobulin class levels in serum and saliva: An investigation and review

N Tarbiah, I Todd, PJ Tighe… - Basic & Clinical …, 2019 - Wiley Online Library
The aim of the present study was to compare concentrations of IgG, IgA, IgM and IgD in both
serum and saliva samples from smoking and non‐smoking individuals using a protein …

CpG sites associated with cigarette smoking: analysis of epigenome-wide data from the Sister Study

S Harlid, Z Xu, V Panduri, DP Sandler… - Environmental health …, 2014 - ehp.niehs.nih.gov
Background: Smoking increases the risk of many diseases, and it is also linked to blood
DNA methylation changes that may be important in disease etiology. Objectives: We sought …

AQP8 transports NOX2-generated H2O2 across the plasma membrane to promote signaling in B cells

M Bertolotti, G Farinelli, M Galli, A Aiuti… - Journal of Leucocyte …, 2016 - academic.oup.com
H2O2 acts as a second messenger in key signaling circuits, transiently modulating tyrosine
phosphatases and kinases. We investigated its origin, membrane transport, and functional …

Differential gene expression patterns between smokers and non‐smokers: cause or consequence?

JM Vink, R Jansen, A Brooks, G Willemsen… - Addiction …, 2017 - Wiley Online Library
The molecular mechanisms causing smoking‐induced health decline are largely unknown.
To elucidate the molecular pathways involved in cause and consequences of smoking …

Astrocyte-specific overexpressed gene signatures in response to methamphetamine exposure in vitro

N Bortell, L Basova, S Semenova, HS Fox… - Journal of …, 2017 - Springer
Background Astrocyte activation is one of the earliest findings in the brain of
methamphetamine (Meth) abusers. Our goal in this study was to identify the characteristics …

[HTML][HTML] Differential effect of active smoking on gene expression in male and female smokers

S Paul, SA Amundson - Journal of carcinogenesis & mutagenesis, 2014 - ncbi.nlm.nih.gov
Smoking is the second leading cause of preventable death in the United States. Cohort
epidemiological studies have demonstrated that women are more vulnerable to cigarette …

Viral and immunologic evaluation of smokers with severe COVID-19

J Vecchio, J Regan, Y Jiang, R Li, H Romain… - Scientific Reports, 2023 - nature.com
Smoking negatively affects B cell function and immunoglobulin levels, but it is unclear if this
immune dysfunction contributes to the risk of severe COVID-19 in smokers. We evaluated …

Stem cell-derived endothelial cell model that responds to tobacco smoke like primary endothelial cells

PH Chu, G Chen, D Kuo, J Braisted… - Chemical research in …, 2020 - ACS Publications
To clarify how smoking leads to heart attack and stroke, we developed an endothelial cell
model (iECs) generated from human induced Pluripotent Stem Cells (iPSC) and evaluated …

Differential expression of lung adenocarcinoma transcriptome with signature of tobacco exposure

RY Hammouz, JK Kostanek, A Dudzisz, P Witas… - Journal of Applied …, 2020 - Springer
Abstract Smoking accounts for almost 80–90% of lung cancer cases, which is also the most
frequent cause of cancer-related deaths in humans. With over 60 carcinogens in tobacco …