How do chemotherapeutic agents damage the ovary?

S Morgan, RA Anderson, C Gourley… - Human reproduction …, 2012 - academic.oup.com
BACKGROUND Chemotherapy treatment in premenopausal women is associated with an
increased risk of premature ovarian failure (POF) but the exact mechanism through which …

Protective effects of curcumin against doxorubicin-induced toxicity and resistance: A review

M Mohajeri, A Sahebkar - Critical reviews in oncology/hematology, 2018 - Elsevier
Doxorubicin (DOX)-induced toxicity and resistance are major obstacles in chemotherapeutic
approaches. Despite effective in the treatment of numerous malignancies, some clinicians …

Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal

S Song, L Chu, H Liang, J Chen, J Liang… - Frontiers in …, 2019 - frontiersin.org
Doxorubicin (Dox), an antitumor antibiotic, has therapeutic effects on many kinds of tumors.
However, Dox can produce some serious side effects that limit its clinical application. Thus …

Propolis attenuates doxorubicin-induced testicular toxicity in rats

SM Rizk, HF Zaki, MAM Mina - Food and chemical toxicology, 2014 - Elsevier
Doxorubicin (Dox), an effective anticancer agent, can impair testicular function leading to
infertility. The present study aimed to explore the protective effect of propolis extract on Dox …

Mechanisms of doxorubicin-mediated reproductive toxicity–a review

UP Mohan, TP PB, STA Iqbal, S Arunachalam - Reproductive Toxicology, 2021 - Elsevier
The anticancer drug doxorubicin has been associated with several adverse side-effects
including reproductive toxicity in both genders. The current review has complied the …

How does chemotherapy treatment damage the prepubertal testis?

CM Allen, F Lopes, RT Mitchell, N Spears - Reproduction, 2018 - rep.bioscientifica.com
Chemotherapy treatment is a mainstay of anticancer regimens, significantly contributing to
the recent increase in childhood cancer survival rates. Conventional cancer therapy targets …

Impact of ellagic acid on adriamycin-induced testicular histopathological lesions, apoptosis, lipid peroxidation and sperm damages

AO Çeribaşı, F Sakin, G Türk, M Sönmez… - … and toxicologic pathology, 2012 - Elsevier
The aim of the present study was to investigate whether ellagic acid (EA) has protective
effect on adriamycin (ADR)-induced testicular and spermatozoal toxicity associated with the …

Exposure to benzo (a) pyrene from juvenile period to peripubertal impairs male reproductive parameters in adult rats

BC Jorge, ACC Reis, ÉT Sterde, P da Silva Balin… - Chemosphere, 2021 - Elsevier
Abstract Benzo (a) pyrene (BaP) is a persistent organic pollutant and endocrine disruptor
that can compromise the steroidogenesis process by interacting with the StAR protein …

Palliative effect of curcumin on doxorubicin‐induced testicular damage in male rats

EH Aksu, FM Kandemir, S Yıldırım… - … of biochemical and …, 2019 - Wiley Online Library
This study aimed to investigate the effect of curcumin (CUR) on doxorubicin (DOX)‐induced
testicular damage in male rats. Thirty‐five adult male Wistar rats were used. Control group …

Neutrophil recruitment and phagocytosis of boar spermatozoa after artificial insemination of sows, and the effects of inseminate volume, sperm dose and specific …

A Matthijs, B Engel, H Woelders - Reproduction, 2003 - rep.bioscientifica.com
Telocytes (TCs) have been described in various organs and species (www. telocytes. com)
as cells with telopodes (Tps)–very long cellular extensions with an alternation of thin …