Acinetobacter baumannii: Envelope Determinants That Control Drug Resistance, Virulence, and Surface Variability

E Geisinger, W Huo, J Hernandez-Bird… - Annual review of …, 2019 - annualreviews.org
Acinetobacter baumannii has emerged as an important nosocomial pathogen, particularly
for patients in intensive care units and with invasive indwelling devices. The most recent …

Acinetobacter baumannii regulates its stress responses via the BfmRS two-component regulatory system

S Palethorpe, JM Farrow III, G Wells… - Journal of …, 2022 - Am Soc Microbiol
Acinetobacter baumannii is a common nosocomial pathogen that utilizes numerous
mechanisms to aid its survival in both the environment and the host. Coordination of such …

Recent Advances in Genetic Tools for Acinetobacter baumannii

EME Sykes, S Deo, A Kumar - Frontiers in Genetics, 2020 - frontiersin.org
Acinetobacter baumannii is classified as a top priority pathogen by the World Health
Organization (WHO) because of its widespread resistance to all classes of antibiotics. This …

Essential gene analysis in Acinetobacter baumannii by high-density transposon mutagenesis and CRISPR interference

J Bai, Y Dai, A Farinha, AY Tang, S Syal… - Journal of …, 2021 - Am Soc Microbiol
Acinetobacter baumannii is a poorly understood bacterium capable of life-threatening
infections in hospitals. Few antibiotics remain effective against this highly resistant …

Inactivation of AdeABC and AdeIJK efflux pumps elicits specific nonoverlapping transcriptional and phenotypic responses in Acinetobacter baumannii

IV Leus, J Adamiak, AN Trinh, RD Smith… - Molecular …, 2020 - Wiley Online Library
Multidrug resistant (MDR) strains of Acinetobacter baumannii present a serious clinical
challenge. The development of antibiotic resistance in this species is enabled by efflux …

Stochastic activation of a family of TetR type transcriptional regulators controls phenotypic heterogeneity in Acinetobacter baumannii

M Pérez-Varela, ARP Tierney, E Dawson… - PNAS …, 2022 - academic.oup.com
Phenotypic heterogeneity is an important mechanism for regulating bacterial virulence,
where a single regulatory switch is typically activated to generate virulent and avirulent …

Acinetobactin-mediated inhibition of commensal bacteria by Acinetobacter baumannii

GA Knauf, MJ Powers, CM Herrera, MS Trent… - Msphere, 2022 - Am Soc Microbiol
Acinetobacter baumannii is an important hospital-associated pathogen that causes antibiotic
resistant infections and reoccurring hospital outbreaks. A. baumannii's ability to …

A LysR-Type Transcriptional Regulator Controls Multiple Phenotypes in Acinetobacter baumannii

ARP Tierney, CY Chin, DS Weiss… - Frontiers in Cellular and …, 2021 - frontiersin.org
Acinetobacter baumannii is a multidrug-resistant, Gram-negative nosocomial pathogen that
exhibits phenotypic heterogeneity resulting in virulent opaque (VIR-O) and avirulent …

The novel two-component system AmsSR governs alternative metabolic pathway usage in Acinetobacter baumannii

LG Casella, NJ Torres, BR Tomlinson… - Frontiers in …, 2023 - frontiersin.org
In this study, we identify a novel two-component system in Acinetobacter baumannii (herein
named AmsSR for regulator of alternative metabolic systems) only present in select …

[HTML][HTML] 'GGFGGQ'repeats in Hfq of Acinetobacter baumannii are essential for nutrient utilization and virulence

A Sett, PK Maiti, K Garg, A Hussain, S Saini… - Journal of Biological …, 2024 - Elsevier
The nosocomial pathogen Acinetobacter baumannii is known for causing lung and soft
tissue infections in immunocompromised hosts. Its ability to adapt to various environments …