The first step of the human immunodeficiency virus (HIV) replication cycle—binding and
entry into the host cell—plays a major role in determining viral tropism and the ability of HIV …

Over the past three decades of intense research on the contribution of viral and host factors
determining the variability in HIV-1 infection outcome, HIV pathogenesis is still a fascinating …

Double-stranded RNAs≈ 21 nucleotides long [small interfering RNA (siRNA)] are
recognized as powerful reagents to reduce the expression of specific genes. To use them as …

The coreceptor discoveries revealed new insights into host and viral factors influencing HIV
transmission and disease. The HIV/coreceptor interaction has become a major target for the …

ABSTRACT CCR5 serves as a requisite fusion coreceptor for clinically relevant strains of
human immunodeficiency virus type 1 (HIV-1) and provides a promising target for antiviral …

A genetic basis for interindividual variation in susceptibility to human infectious diseases has
been indicated by twin, adoptee, pedigree, and candidate gene studies. This has led to the …

The pivotal discovery that two chemokine receptors, CCR5 and CXCR4, serve along with
the T-cell receptor-interacting CD4 molecule as the principal co-receptors for HIV-1 entry …

Entry of human immunodeficiency virus type 1 (HIV-1) into target cells requires both CD4
(ref. 1, 2) and one of a growing number of C-protein-coupled seven-transmembrane …

Viruses of the subfamily Orthoretrovirinae are defined by the ability to reverse transcribe an
RNA genome into DNA that integrates into the host cell genome during the intracellular virus …

The CC chemokine receptor type 5 (CCR5) is a key player in HIV infection due to its major
involvement in the infection process. Investigations into the role of the CCR5 coreceptor first …