The discovery of corticotropin-releasing factor (CRF) or CRH defining the upper regulatory
arm of the hypothalamic-pituitary-adrenal (HPA) axis, along with the identification of the …

Type 2 diabetes is associated with several potential comorbidities, among them impaired
wound healing, chronic ulcerations, and the requirement for lower extremity amputation …

Due to the close interactions between the skin and peripheral nervous system, there is
increasing evidence that the cutaneous innervation is an important modulator of the normal …

Non-thyroidal illness syndrome (NTIS) is part of the neuroendocrine response to stress, but
the significance of this syndrome remains uncertain. The aim of this study was to investigate …

Background: Human dermal fibroblasts (HDF) can be used as a cellular model relatively
easily and without genetic engineering. Therefore, HDF represent an interesting tool to study …

Our objective was to investigate the mechanisms by which the endogenous CRHR2 in white
adipose tissue (WAT) regulates metabolic activities associated with lipogenesis and lipolysis …

The corticotropin-releasing hormone family mediates functional responses in many organs,
including the intestine. Activation of corticotropin-releasing hormone receptor 2 (CRHR2) in …

Volume hyposensitivity resulting from impaired sympathetic detrusor relaxation during
bladder filling contributes to detrusor underactivity (DU) associated with aging. Detrusor …

Since its discovery in biopsies from breast cancer patients, the effect of corticotropin-
releasing hormone (CRH) on carcinoma progression is still unclear. Transforming growth …

Objective: In healthy individuals, leptin is produced from adipose tissue and is secreted into
the circulation to communicate energy balance status to the brain and control fat …