Hazard assessment of polymeric nanobiomaterials for drug delivery: what can we learn from literature so far

S Jesus, M Schmutz, C Som, G Borchard… - … in bioengineering and …, 2019 - frontiersin.org
The physicochemical properties of nanobiomaterials, such as their small size and high
surface area ratio, make them attractive, novel drug-carriers, with increased cellular …

Advances in preparation of chitooligosaccharides with heterogeneous sequences and their bioactivity

W Hao, K Li, P Li - Carbohydrate Polymers, 2021 - Elsevier
Chitooligosaccharides has attracted increasing attention due to their diverse bioactivities
and potential application. Previous studies on the bioactivity of chitooligosaccharides were …

Chitosan nanoparticles: shedding light on immunotoxicity and hemocompatibility

S Jesus, AP Marques, A Duarte, E Soares… - … in bioengineering and …, 2020 - frontiersin.org
Nanoparticles (NPs) assumed an important role in the area of drug delivery. Despite the
number of studies including NPs are growing over the last years, their side effects on the …

In vitro biological response of human osteoblasts in 3D chitosan sponges with controlled degree of deacetylation and molecular weight

M Sukul, P Sahariah, HL Lauzon, J Borges… - Carbohydrate …, 2021 - Elsevier
We have studied the effect of chitosan sponges, produced from chitosan batches with
distinct degree of deacetylation (DDA) and molecular weight (Mw), on the adhesion, growth …

Chitosan oligosaccharide regulates AMPK and STAT1 pathways synergistically to mediate PD-L1 expression for cancer chemoimmunotherapy

J Chen, Z Zhou, C Zheng, Y Liu, R Hao, X Ji, Q Xi… - Carbohydrate …, 2022 - Elsevier
After regular chemotherapy, the expression of programmed cell death ligand 1 (PD-L1) in
almost all kinds of cancers is significantly increased, leading to reduced efficacy of T cell …

[图书][B] Chitin and chitosan derivatives: advances in drug discovery and developments

SK Kim - 2013 - books.google.com
A natural long-chain polymer, chitin is the main component of the cell walls of fungi, the
exoskeletons of arthropods (including crustaceans and insects), the radulas of mollusks, and …

Chitooligosaccharides inhibit tumor progression and induce autophagy through the activation of the p53/mTOR pathway in osteosarcoma

Z Pan, D Cheng, X Wei, S Li, H Guo, Q Yang - Carbohydrate Polymers, 2021 - Elsevier
Osteosarcoma is the most common primary sarcoma of bone. The use of
Chitooligosaccharide (COS) as a drug carrier is an emerging new strategy for cancer …

Nanoparticle impact on innate immune cell pattern-recognition receptors and inflammasomes activation

AL Silva, C Peres, J Conniot, AI Matos, L Moura… - Seminars in …, 2017 - Elsevier
Nanotechnology-based strategies can dramatically impact the treatment, prevention and
diagnosis of a wide range of diseases. Despite the unprecedented success achieved with …

Chitin derivatives ameliorate DSS-induced ulcerative colitis by changing gut microbiota and restoring intestinal barrier function

Z Mei, X Huang, H Zhang, D Cheng, X Xu… - International Journal of …, 2022 - Elsevier
Chitin derivatives (CDs), including chitosan (CS), chitooligosaccharides (COS), and
glucosamine (GlcN), were administrated in dextran sodium sulfate (DSS)-induced ulcerative …

Osteoinductive and anti-inflammatory properties of chitosan-based scaffolds for bone regeneration

I Fasolino, MG Raucci, A Soriente, C Demitri… - Materials Science and …, 2019 - Elsevier
Current bone implants based on new biomaterials may cause a foreign body reaction (FBR)
around the implant itself thus prolonging the healing time following bone fractures. In this …