Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system

EM Hol, M Pekny - Current opinion in cell biology, 2015 - Elsevier
Glial fibrillary acidic protein (GFAP) is the hallmark intermediate filament (IF; also known as
nanofilament) protein in astrocytes, a main type of glial cells in the central nervous system …

[HTML][HTML] Gut microbial metabolites in depression: understanding the biochemical mechanisms

G Caspani, S Kennedy, JA Foster, J Swann - Microbial Cell, 2019 - ncbi.nlm.nih.gov
Gastrointestinal and central function are intrinsically connected by the gut microbiota, an
ecosystem that has co-evolved with the host to expand its biotransformational capabilities …

May the force be with you: the light and dark sides of the microbiota–gut–brain axis in neuropsychiatry

E Sherwin, KV Sandhu, TG Dinan, JF Cryan - CNS drugs, 2016 - Springer
The role of the gut microbiota in health and disease is becoming increasingly recognized.
The microbiota–gut–brain axis is a bi-directional pathway between the brain and the …

[HTML][HTML] Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration

M Neal, JR Richardson - Biochimica et Biophysica Acta (BBA)-Molecular …, 2018 - Elsevier
Epigenetic mechanisms control various functions throughout the body, from cell fate
determination in development to immune responses and inflammation. Neuroinflammation …

Dietary fiber modulates the release of gut bacterial products preventing cognitive decline in an Alzheimer's mouse model

D Cuervo-Zanatta, T Syeda, V Sánchez-Valle… - Cellular and molecular …, 2023 - Springer
Fiber intake is associated with a lower risk for Alzheimer´ s disease (AD) in older adults.
Intake of plant-based diets rich in soluble fiber promotes the production of short-chain fatty …

Regulation of GFAP expression

M Brenner, A Messing - ASN neuro, 2021 - journals.sagepub.com
Expression of the GFAP gene has attracted considerable attention because its onset is a
marker for astrocyte development, its upregulation is a marker for reactive gliosis, and its …

Intermediate filaments in cell migration and invasion: the unusual suspects

C Leduc, S Etienne-Manneville - Current opinion in cell biology, 2015 - Elsevier
Cell migration is a multistep process which relies on the coordination of cytoskeletal
structures in space and time. While the roles of actin and microtubules have been …

The role of altered protein acetylation in neurodegenerative disease

F Kabir, R Atkinson, AL Cook, AJ Phipps… - Frontiers in Aging …, 2023 - frontiersin.org
Acetylation is a key post-translational modification (PTM) involved in the regulation of both
histone and non-histone proteins. It controls cellular processes such as DNA transcription …

Dietary fibers and their fermented short-chain fatty acids in prevention of human diseases

KN Prasad, SC Bondy - Bioactive carbohydrates and dietary fibre, 2019 - Elsevier
Many studies show that daily consumption of high-fiber diet reduces the risk of developing
kidney stones, inflammatory disease, colon cancer and other malignancies, obesity, type II …

Short-chain fatty acids in the microbiota–gut–brain axis: role in neurodegenerative disorders and viral infections

A Majumdar, IP Siva Venkatesh… - ACS Chemical …, 2023 - ACS Publications
The gut–brain axis (GBA) is the umbrella term to include all bidirectional communication
between the brain and gastrointestinal (GI) tract in the mammalian body. Evidence from over …