Biomolecular condensates, formed through phase separation, are upending our
understanding in much of molecular, cell, and developmental biology. There is an urgent …

The inorganic biopolymer polyphosphate (polyP) occurs in all domains of life and affects
myriad cellular processes. A longstanding observation is polyP's frequent proximity to …

Inferring the 3D structure and conformation of disordered biomolecules, eg, single stranded
nucleic acids (ssNAs), remains challenging due to their conformational heterogeneity in …

Biomolecular condensation and phase separation are increasingly understood to play
crucial roles in cellular compartmentalization and spatiotemporal regulation of cell …

The phase separation of protein and RNA mixtures underpins the assembly and regulation
of numerous membraneless organelles in cells. The ubiquity of protein–RNA condensates in …

Interplay between divalent cations (Mg2+ and Ca2+) and single-stranded DNA (ssDNA) and
double-stranded DNA (dsDNA), as well as stacking interactions, is important in nucleosome …

RNA polymerase II (Pol II) C-terminal domain (CTD) is known to have crucial roles in
regulating transcription. CTD has also been highly recognized for undergoing phase …

RNA–RNA association and phase separation appear to be essential for the assembly of
stress granules and underlie RNA foci formation in repeat expansion disorders. RNA …

RNA molecules are essential in orchestrating the assembly of biomolecular condensates
and membraneless compartments in cells. Many condensates form via the association of …

Cellular condensates are membraneless organelles formed through phase separation or
related processes, but they need not be amorphous blobs. Many display internal structure …