[HTML][HTML] mRNA vaccines for COVID-19: what, why and how
JW Park, PNP Lagniton, Y Liu… - International journal of …, 2021 - ncbi.nlm.nih.gov
Abstract The Coronavirus disease-19 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2), has impacted human lives in the most …
respiratory syndrome coronavirus-2 (SARS-CoV-2), has impacted human lives in the most …
Opportunities and challenges in the delivery of mRNA-based vaccines
In the past few years, there has been increasing focus on the use of messenger RNA
(mRNA) as a new therapeutic modality. Current clinical efforts encompassing mRNA-based …
(mRNA) as a new therapeutic modality. Current clinical efforts encompassing mRNA-based …
Nanoplatforms for mRNA therapeutics
C Meng, Z Chen, G Li, T Welte… - Advanced Therapeutics, 2021 - Wiley Online Library
Abstract mRNA‐based therapeutics are a unique class of drugs for treatment of human
diseases. Since in vitro transcribed mRNA molecules have relatively low stability and their …
diseases. Since in vitro transcribed mRNA molecules have relatively low stability and their …
Cytidine-containing tails robustly enhance and prolong protein production of synthetic mRNA in cell and in vivo
Synthetic mRNAs are rising rapidly as alternative therapeutic agents for delivery of proteins.
However, the practical use of synthetic mRNAs has been restricted by their low cellular …
However, the practical use of synthetic mRNAs has been restricted by their low cellular …
Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA
Human induced pluripotent stem cell (h-iPSC)–derived endothelial cells (h-iECs) have
become a valuable tool in regenerative medicine. However, current differentiation protocols …
become a valuable tool in regenerative medicine. However, current differentiation protocols …
Integrated mRNA sequence optimization using deep learning
The coronavirus disease of 2019 pandemic has catalyzed the rapid development of mRNA
vaccines, whereas, how to optimize the mRNA sequence of exogenous gene such as …
vaccines, whereas, how to optimize the mRNA sequence of exogenous gene such as …
Building human artery and vein endothelial cells from pluripotent stem cells, and enduring mysteries surrounding arteriovenous development
Owing to their manifold roles in health and disease, there have been intense efforts to
synthetically generate blood vessels in vitro from human pluripotent stem cells (hPSCs) …
synthetically generate blood vessels in vitro from human pluripotent stem cells (hPSCs) …
Self-amplifying mRNA vaccines: Mode of action, design, development and optimization
MM Pourseif, Y Masoudi-Sobhanzadeh, E Azari… - Drug Discovery …, 2022 - Elsevier
Highlights•The mRNA-based vaccines are tunable quality-by-design immunotherapy
modalities for different diseases.•Self-amplifying mRNA (saRNA) vaccines, a kind of mRNA …
modalities for different diseases.•Self-amplifying mRNA (saRNA) vaccines, a kind of mRNA …
A streamlined method to generate endothelial cells from human pluripotent stem cells via transient doxycycline-inducible ETV2 activation
The development of reliable methods for producing functional endothelial cells (ECs) is
crucial for progress in vascular biology and regenerative medicine. In this study, we present …
crucial for progress in vascular biology and regenerative medicine. In this study, we present …
Effective and rapid generation of functional neutrophils from induced pluripotent stem cells using ETV2-modified mRNA
VS Brok-Volchanskaya, DA Bennin, K Suknuntha… - Stem Cell Reports, 2019 - cell.com
Human induced pluripotent stem cells (hiPSCs) can serve as a versatile and scalable
source of neutrophils for biomedical research and transfusion therapies. Here we describe a …
source of neutrophils for biomedical research and transfusion therapies. Here we describe a …