The molecular hybridization of different compounds with known pharmacological activity is a
particularly prominent approach for the design of potential drugs with improved …

As microbial resistance to drugs continues to rise at an alarming rate, finding new ways to
combat pathogens is an issue of utmost importance. Development of novel and specific …

Fasciolosis caused by Fasciola hepatica severely affects the efficiency of livestock
production systems worldwide. In addition to the economic impact inflicted on livestock …

Schistosomiasis is a neglected parasitic tropical disease that claims around 200,000 human
lives every year. Praziquantel (PZQ), the only drug recommended by the World Health …

Pyridine nucleotide-disulfide oxidoreductases are underexplored as drug targets, and
thioredoxin reductases (TrxRs) stand out as compelling pharmacological targets. Selective …

Significance: Platyhelminth parasites cause chronic infections that are a major cause of
disability, mortality, and economic losses in developing countries. Maintaining redox …

Fascioliasis is caused by the helminth parasites of genus Fasciola. Thioredoxin glutathione
reductase (TGR) is an important enzyme in parasitic helminths and plays an indispensable …

The mammalian thioredoxin system is driven by NADPH through the activities of isoforms of
the selenoprotein thioredoxin reductase (TXNRD, TrxR), which in turn help to keep …

The enzyme glucose-6-phosphate dehydrogenase (G6PDH) plays crucial roles in glucose
homeostasis and the pentose phosphate pathway (PPP), being also involved in redox …

Alveolar and cystic echinococcosis, caused by the metacestode larval stages of the
tapeworms Echinococcus multilocularis and Echinococcus granulosus, respectively, are life …