In silico investigation and potential therapeutic approaches of natural products for COVID-19: Computer-aided drug design perspective
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a
substantial number of deaths around the world, making it a serious and pressing public …
substantial number of deaths around the world, making it a serious and pressing public …
Possible potential effects of honey and its main components against Covid-19 infection
F Abedi, S Ghasemi, T Farkhondeh… - Dose …, 2021 - journals.sagepub.com
Coronavirus disease 2019 (COVID-19) is a viral pneumonia that is spreading rapidly
worldwide. The main feature of this disease is a severe acute respiratory syndrome and …
worldwide. The main feature of this disease is a severe acute respiratory syndrome and …
Kaempferol derivatives as antiviral drugs against the 3a channel protein of coronavirus
The protein coded by the open-reading-frame 3a of SARS coronavirus has been
demonstrated to form a cation-selective channel that may become expressed in the infected …
demonstrated to form a cation-selective channel that may become expressed in the infected …
Mechanism of influenza A M2 transmembrane domain assembly in lipid membranes
ER Georgieva, PP Borbat, HD Norman, JH Freed - Scientific reports, 2015 - nature.com
M2 from influenza A virus functions as an oligomeric proton channel essential for the viral
cycle, hence it is a high-priority pharmacological target whose structure and functions …
cycle, hence it is a high-priority pharmacological target whose structure and functions …
Targeting the channel activity of viroporins
Since the discovery that certain small viral membrane proteins, collectively termed as
viroporins, can permeabilize host cellular membranes and also behave as ion channels …
viroporins, can permeabilize host cellular membranes and also behave as ion channels …
Viral membrane channels: role and function in the virus life cycle
CW Sze, YJ Tan - Viruses, 2015 - mdpi.com
Viroporins are small, hydrophobic trans-membrane viral proteins that oligomerize to form
hydrophilic pores in the host cell membranes. These proteins are crucial for the …
hydrophilic pores in the host cell membranes. These proteins are crucial for the …
What are the effects of the serine triad on proton conduction of an influenza B M2 channel? An investigation by molecular dynamics simulations
Y Zhang, QC Zheng - Physical Chemistry Chemical Physics, 2019 - pubs.rsc.org
The tetrameric influenza B M2 channel (BM2), an acid activated proton channel, is important
in the influenza virus B lifecycle. A conserved HxxxW motif is responsible for proton …
in the influenza virus B lifecycle. A conserved HxxxW motif is responsible for proton …
[HTML][HTML] Genotype-specific differences in structural features of hepatitis C virus (HCV) p7 membrane protein
The 63 amino acid polytopic membrane protein, p7, encoded by hepatitis C virus (HCV) is
involved in the modulation of electrochemical gradients across membranes within infected …
involved in the modulation of electrochemical gradients across membranes within infected …
Data hazards in synthetic biology
Data science is playing an increasingly important role in the design and analysis of
engineered biology. This has been fueled by the development of high-throughput methods …
engineered biology. This has been fueled by the development of high-throughput methods …
Membrane undulation induced by NS4A of Dengue virus: a molecular dynamics simulation study
Nonstructural protein 4A (NS4A) of Dengue virus (DENV) is a membrane protein involved in
rearrangements of the endoplasmic reticulum membrane that are required for formation of …
rearrangements of the endoplasmic reticulum membrane that are required for formation of …