Sickle cell disease (SCD) is an autosomal recessive genetic disorder that occurs due to the
point mutation in the β‐globin gene, which results in the formation of sickle hemoglobin …

Abnormal red blood cell (RBC) deformability contributes to hemolysis, thrombophilia,
inflammation, and microvascular occlusion in various circulatory diseases. A quantitative …

Hydroxyurea is FDA‐approved and now increasingly used for children with sickle cell
anemia (SCA), but dosing strategies, pharmacokinetic (PK) profiles, and treatment …

The Schlafen (SLFN) 11 gene has been implicated in various biological processes such as
suppression of HIV replication, replication stress response, and sensitization of cancer cells …

Hydroxyurea treatment for children with sickle cell anemia (SCA) is effective and life‐saving.
Stepwise escalation to maximum tolerated dose (MTD) provides optimal benefits, but is …

Purpose Esophageal cancer (EC) is an aggressive malignancy and is often resistant to
currently available therapies. Inhibition of ribonucleotide reductase small subunit M2 …

Background Sickle cell disease (SCD) is a severe and devastating hematological disorder
that affects over 100,000 persons in the USA and millions worldwide. Hydroxyurea is the …

Introduction: Hydroxyurea is effective disease-modifying treatment for sickle cell anemia
(SCA). Escalation to maximum tolerated dose (MTD) achieves superior benefits without …

The study involves preparing starch nanocrystals by acid hydrolysis of starch and to produce
a new chemical crosslinking starch nanocrystals/gum Arabic blend in the presence of …

Hydroxyurea (HU) has shown promise in breast cancer treatment, but its hydrophilic nature
limits its efficacy. Therefore, conjugating HU with lipids could increase its liphophilicity and …