Aims Evaluating the public health impact of regulatory interventions is important but there is
currently no common methodological approach to guide this evaluation. This systematic …

Background: After market approval, new serious safety issues are regularly identified for
drugs that lead to regulatory action to inform healthcare professionals. However, the …

Following the FDA black box warning in 2004, substantial reductions in antidepressant
(ATD) use were observed within 2 years in children and adolescents in several countries …

Purpose The number of antidepressants prescribed in the UK has been increasing over the
last 25 years; however, the reasons for this are not clear. This study examined trends in …

BackgroundSelf-harm is a common reason for presentation to a general hospital, with a
strong association with suicide. Trends in self-harm are an important indicator of community …

We examined epidemiology and characteristics of self-harm in adolescents and impact of
national guidance on management. Data were collected in six hospitals in three centres …

Aims Regulatory risk communications are important to ensure medication safety, but their
impact is poorly understood. The aim was to quantify the impact of UK risk communications …

Objective To assess trends in the use of antidepressants among young suicides after the
warning that these drugs might increase the risk of suicide. Method Individual data of all 845 …

Methods Using data from the French Health Insurance Database, annual prevalence and
incidence of ATD use and changes in ATD prescribing patterns were analyzed. Results …

Every year thousands of children and young people attend emergency departments with
problems resulting from self-harm. More still come to the attention of CAMHS teams, school …