Plasmodium vivax parasites cause the majority of malaria cases outside Africa, and are
increasingly being acknowledged as a cause of severe disease. The unique attributes of P …

Modern controlled human malaria infection (CHMI) clinical trials have almost entirely
focussed on Plasmodium falciparum, providing a highly informative means to investigate …

Controlled human malaria infection (CHMI) provides a highly informative means to
investigate host-pathogen interactions and enable in vivo proof-of-concept efficacy testing of …

Almost invariably, humans become ill during primary infections with malaria parasites which
is a pathology associated with oxidative stress and perturbations in metabolism. Importantly …

The complexity of the Plasmodium parasite and its life cycle poses a challenge to our
understanding of the host immune response against malaria. Studying human immune …

Objectives To dissect the transcriptional networks underpinning immune cells responses
during primary Plasmodium vivax infection of healthy human adults. Methods We conducted …

Background Plasmodium vivax (P. vivax) is the dominant Plasmodium spp. causing the
disease malaria in low-transmission regions outside of Africa. These regions often feature …

Malaria sterile immunity has been reproducibly induced by immunization with Plasmodium
radiation-attenuated sporozoites (RAS). Analyses of sera from RAS-immunized individuals …

Understanding naturally acquired immune responses to Plasmodium in India is key to
improving malaria surveillance and diagnostic tools. Here we describe serological profiling …

Abstract Background Sickle cell trait (HbAS) protects against severe Plasmodium falciparum
malaria but not against placental malaria (PM). In this study, P falciparum erythrocyte …