Deficits in cognition, reward processing, and motor function are clinical features relevant to
both aging and depression. Individuals with late-life depression often show impairment …

Exogenous administration of inflammatory stimuli to humans and laboratory animals and
chronic endogenous inflammatory states lead to motivational deficits and ultimately …

Increased inflammation in major depressive disorder (MDD) has been associated with low
functional connectivity (FC) in corticostriatal reward circuits and symptoms of anhedonia …

Dopamine and its receptors are currently recognized targets for the treatment of several
neuropsychiatric disorders, including Parkinson's disease, schizophrenia, some drug use …

Anhedonia, characterized by a lack of motivation, interest, or ability to experience pleasure,
is a prominent symptom of depression and other psychiatric disorders and has been …

Although the public importance of frailty is widely acknowledged by the World Health
Organization, physical frailty is still largely neglected in geriatric mental health care. Firstly in …

Background To investigate the longitudinal relationship between physical frailty, the clinical
representation of accelerated biological aging, and antidepressant medication response in …

As a traditional Chinese medicine (TCM), Millettia speciosa Champ (MSC), exerts a wide
range of pharmacological activities. Our research group previously found that MSC has …

Objective To investigate the relationship between frailty and treatment response to
antidepressant medications in adults with late life depression (LLD). Methods Data were …

Late-life depression (LLD) is a prevalent and disabling condition in older adults that is often
accompanied by slowed processing and gait speed. These symptoms are related to …