Role of tau protein in Alzheimer's disease: The prime pathological player

S Muralidar, SV Ambi, S Sekaran, D Thirumalai… - International journal of …, 2020 - Elsevier
Alzheimer's disease (AD) is a prevalently found tauopathy characterized by memory loss
and cognitive insufficiency. AD is an age-related neurodegenerative disease with two major …

[HTML][HTML] Molecular mechanisms of ischemia and glutamate excitotoxicity

D Neves, IL Salazar, RD Almeida, RM Silva - Life sciences, 2023 - Elsevier
Excitotoxicity is classically defined as the neuronal damage caused by the excessive
release of glutamate, and subsequent activation of excitatory plasma membrane receptors …

Redox proteomics and amyloid β‐peptide: insights into Alzheimer disease

DA Butterfield, D Boyd‐Kimball - Journal of neurochemistry, 2019 - Wiley Online Library
Alzheimer disease (AD) is a progressive neurodegenerative disorder associated with aging
and characterized pathologically by the presence of senile plaques, neurofibrillary tangles …

Molecular crosstalk between cancer and neurodegenerative diseases

J Seo, M Park - Cellular and Molecular Life Sciences, 2020 - Springer
The progression of cancers and neurodegenerative disorders is largely defined by a set of
molecular determinants that are either complementarily deregulated, or share remarkably …

Peptidyl-Prolyl Cis/Trans Isomerase Pin1 and Alzheimer's Disease

L Wang, Y Zhou, D Chen, TH Lee - Frontiers in cell and …, 2020 - frontiersin.org
Alzheimer's disease (AD) is the most common cause of dementia with cognitive decline. The
neuropathology of AD is characterized by intracellular aggregation of neurofibrillary tangles …

Amyloid beta oligomers target to extracellular and intracellular neuronal synaptic proteins in Alzheimer's disease

Y Ding, J Zhao, X Zhang, S Wang, KL Viola… - Frontiers in …, 2019 - frontiersin.org
Introduction: β-Amyloid protein (Aβ) putatively plays a seminal role in synaptic loss in
Alzheimer's disease (AD). While there is no consensus regarding the synaptic-relevant …

Pin1 and Alzheimer's disease

JS Malter - Translational Research, 2023 - Elsevier
Alzheimer's disease (AD) is an immense and growing public health crisis. Despite over 100
years of investigation, the etiology remains elusive and therapy ineffective. Despite current …

The regulatory role of Pin1 in neuronal death

SC Wang, XM Hu, K Xiong - Neural Regeneration Research, 2023 - journals.lww.com
Regulated cell death predominantly involves apoptosis, autophagy, and regulated necrosis.
It is vital that we understand how key regulatory signals can control the process of cell death …

[HTML][HTML] Determination of molecular signatures and pathways common to brain tissues of autism spectrum disorder: insights from comprehensive bioinformatics …

SA Bristy, AMH Islam, KMS Andalib, U Khan… - Informatics in Medicine …, 2022 - Elsevier
Autism spectrum disorder (ASD) is a collection of neurological disabilities marked by
difficulties with behavior, speech, language, and interaction. It is a complicated and …

Phosphoregulation of the septin cytoskeleton in neuronal development and disease

B Werner, S Yadav - Cytoskeleton, 2023 - Wiley Online Library
Septins are highly conserved GTP‐binding proteins that oligomerize and form higher order
structures. The septin cytoskeleton plays an important role in cellular organization …